Principal Engineer, Downstream Processing

We need to output HTML fragment with sections: About the role? The posting includes intro paragraphs about Lilly, mission, etc. That could be "About the role" or maybe "About Lilly". The instruction: use

for section headings (e.g. About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule). Use

• for any list of duties/requirements/benefits, and

  for prose. Do NOT repeat the job title as a heading (the page already shows it) and do NOT put Job ID / requisition numbers as headings — fold minor metadata into a short

  or drop it. Preserve ALL substantive information; do NOT invent or summarize away detail. Remove cookie/navigation/legal/EEO/equal-opportunity/scam-warning boilerplate, duplicated lines, and application instructions. IMPORTANT: include a section ONLY when the posting has real, specific content for it — never emit a heading followed by filler/placeholder text (e.g. "commensurate with experience", "not specified", "N/A", "varies", "TBD") and never create Pay/Schedule/Benefits sections unless the posting actually states them. Prefer a few substantive sections over many thin ones. Output ONLY the HTML fragment — no /, no markdown code fences. We need to decide which sections to include based on content. Content sections: - Intro about Lilly: mission, location, employees, etc. Could be "About the role" or maybe "About Lilly". The instruction says use headings like About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule. So we can use "About the role" for the introductory description. - Job Summary: description of role, location, responsibilities summary. Could be part of About the role or separate? Probably part of About the role. - Key Responsibilities: list of responsibilities. Use

  • . - Basic Requirements: list of requirements (education, experience). Use
    • . - Additional Preferences: list of preferences. Could be "Skills" or "Qualifications"? The instruction includes Qualifications, Skills. We have Basic Requirements (education/experience) and Additional Preferences (skills, experience). Could combine into Requirements and Qualifications? Let's map: - Basic Requirements: could be "Requirements" (education/experience). Additional Preferences: could be "Qualifications" or "Skills". The instruction says we can use Qualifications, Skills. We'll decide. - Work Environment: mention limited occasional evening or weekend work required. Also Lilly's dedication to disability accommodation etc. That's more about work environment; not a standard heading but could be included as a paragraph under About the role or separate? The instruction only lists certain headings; we should not create new headings not in list unless we think it's needed? It says "use

      for section headings (e.g. About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule)." The e.g. suggests those are examples, not exhaustive? It says "use

      for section headings (e.g. About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule)." Likely they expect us to use those headings when appropriate. We can also use other headings if needed? The instruction: "use

      for section headings (e.g. About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule)." It doesn't forbid other headings, but suggests those are typical. Safer to stick to those. We have content for: About the role (intro + job summary), Responsibilities (Key Responsibilities), Requirements (Basic Requirements), Qualifications/Skills (Additional Preferences). Benefits: there is a paragraph about compensation and benefits: "Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)." That's substantive benefits info. So we should include a Benefits section. Pay: The posting mentions "Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is" but then seems cut off? It says "The anticipated wage for this position is Full-time equivalent employees also will be eligible for a company bonus". It seems incomplete; maybe missing a number. It's vague; not a specific number. According to instruction: never create Pay/Schedule/Benefits sections unless the posting actually states them. It does state compensation depends on factors, and mentions bonus eligibility. That's somewhat specific but not a number. Should we include Pay? It says "Actual compensation will depend on a candidate’s education, experience, skills, and geographic location." That's a statement about pay. It's not placeholder like "commensurate with experience". It's a real statement. So we could include a Pay section with that sentence. However, the instruction says "never emit a heading followed by filler/placeholder text (e.g. "commensurate with experience", "not specified", "N/A", "varies", "TBD")". The phrase "Actual compensation will depend on a candidate’s education, experience, skills, and geographic location." is not filler; it's a real statement. So we can include Pay. Schedule: The posting mentions "Limited occasional evening or weekend work required." That's schedule info. So we can include Schedule section. Thus we have sections: About the role, Responsibilities, Requirements, Qualifications (or Skills), Benefits, Pay, Schedule. We need to decide which heading for Additional Preferences. Could be "Skills" (since they list skills like experience with AAV, hands-on experience, Unicorn software, MS Office, JMP, interpersonal, communication, decision-making). Or "Qualifications". We'll choose "Skills". The Requirements heading will cover Basic Requirements (education/experience). The Skills heading will cover Additional Preferences. Now we need to strip boilerplate: remove cookie/navigation/legal/EEO/equal-opportunity/scam-warning boilerplate, duplicated lines, and application instructions. Also remove accommodation request form link? That's part of EEO/accommodation; it's legal boilerplate. Should be removed. Also remove EEO statement, employee resource groups list? That's also boilerplate. Remove "Lilly is dedicated to helping individuals with disabilities..." etc. Also remove "Lilly is proud to be an EEO Employer..." and the list of ERGs. Also remove "Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response." Also remove "If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance." Also remove "Work Environment Limited occasional evening or weekend work required." Actually that's not boilerplate; it's schedule info. We'll keep that in Schedule section. Also remove "Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees." That's legal boilerplate; remove. Also remove "#WeAreLilly" at end. Also remove duplicated lines? Not seeing duplicates. Now we need to preserve all substantive information. Let's extract substantive content: Intro paragraph(s): "At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us." Job Summary: "To support our growing genetic medicines pipeline, we are seeking to expand expertise of our research-grade pilot manufacturing team at Lilly's Harborside location in Boston, MA. The Principal Engineer, Downstream Processing will provide direct support for the tech transfer of small-scale purification conditions to manufacturing scale (e.g., 250L-derived downstream train). This role will provide expertise required for downstream analyses — including yield and recovery calculations across unit operations, chromatogram interpretation (e.g., peak shape, resolution, area under the curve), filtration performance metrics (e.g., flux decay, TMP trends, membrane fouling indicators) and overall root cause troubleshooting within and between unit operations. This role will be integral in defining the laboratory's downstream technical agenda. The successful applicant will have deep technical expertise in their areas of responsibility and demonstrate strong data-driven problem-solving capabilities." Key Responsibilities (list): - Possess in-depth knowledge and demonstrated technical capability with downstream unit operations including depth filtration, multiple chromatography modes (e.g., affinity, ion exchange, hydrophobic interaction), ultracentrifugation, and tangential flow filtration (TFF). - Collaborate with early and late-phase development organizations to ensure well-understood and robust processes are transferred. - Maintain accurate records and interpret data to provide detailed information and analyses. - Troubleshoot issues as they occur and identify trends and opportunities to reduce process variability and improve product recovery and quality. - Create and review documents including laboratory SOPs, material specifications, protocols, and work instructions. - Flexibility to accept new projects, prioritizations, and challenges. Basic Requirements: - BS degree in biology, chemistry, biochemistry, chemical engineering, or similar discipline with at least 5 years of relevant experience in downstream scale-up/scale-down process development. - MS degree in biology, chemistry, biochemistry, chemical engineering, or similar discipline with at least 3 years of relevant experience in downstream scale-up/scale-down process development. - PhD will not be considered at this job level - Qualified applicants must be authorized to work in the United States on a full-time basis. - Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1. Additional Preferences (Skills): - Direct experience with purification of recombinant AAV and/or lentivirus. - Hands-on experience with mammalian and/or insect cell derived feed streams. - Exposure to process automation and single-use technologies. - Working knowledge of Unicorn software. - Proficiency in Microsoft Office and statistical analysis software (e.g., JMP). - Detail-oriented, self-motivated, and excited to take on new challenges. - Demonstrated strong interpersonal skills. - Demonstrated strong verbal and written communication skills. - Demonstrated ability to participate in and facilitate decision-making. Work Environment / Schedule: - Limited occasional evening or weekend work required. Benefits: - Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. - The anticipated wage for this position is Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). - In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program