Principal Cyber Security Architecture Lead - USA Remote

About the role

At Danaher, our work saves lives. Each of us plays a part in turning ideas into impact—innovating at the speed of life. As the Principal Cyber Security Architecture Lead, you will provide strategic leadership for a team of security architects and partner closely with architecture, engineering, data, AI, and infrastructure teams to design and deliver secure enterprise solutions. This role integrates security throughout the solution lifecycle, champions Secure by Design principles, and serves as a trusted advisor to business and technology stakeholders.

You will identify, assess, and mitigate cybersecurity risks while driving the implementation of security controls across traditional, cloud, SaaS, AI, generative AI, and agentic AI environments. This position is part of the Danaher Corporate Information Security organization, reports to the Director of Cyber Architecture, Engineering, & Operations, and is fully remote.

Responsibilities

• Develop and maintain comprehensive security architectures, policies, protocols, standards, and guardrails for applications, data pipelines, AI solutions, and critical business systems, ensuring alignment with cybersecurity best practices, enterprise governance, and regulatory requirements.
• Conduct threat modeling, risk validation, and security assessments to identify vulnerabilities across software, infrastructure, data sets, and AI solutions; develop mitigation strategies for risks including unauthorized access, data breaches, data tampering, adversarial attacks, and other cyber threats.
• Define and implement security requirements for enterprise AI deployments, including identity and access management, least-privilege controls, data classification, logging, monitoring, red teaming, human-in-the-loop controls, and responsible AI governance.
• Partner closely with cross-functional stakeholders across architecture, engineering, development, data science, DevOps, AI, privacy, legal, compliance, and business teams to embed security throughout the solution lifecycle, review AI use cases, and ensure compliance with cybersecurity, data protection, and regulatory requirements before production deployment.
• Select, implement, and automate enterprise security technologies and monitoring capabilities, including anomaly detection platforms, vulnerability scanning tools, and other solutions that strengthen and integrate security controls across the broader cybersecurity framework.

Requirements

• 7+ years of progressive experience designing and securing on-premises, cloud, and hybrid enterprise architectures, with a strong understanding of secure system design principles.
• Deep expertise in enterprise security technologies and practices, including cryptography, secure data storage, secure communications, threat intelligence, vulnerability management, and incident response.
• Demonstrated knowledge of AI and machine learning security, including risks associated with large language models (LLMs), generative AI applications, agentic AI systems, prompt flows, data pipelines, model integrations, and enterprise AI platforms.
• Experience defining and implementing AI security guardrails and governance frameworks, including identity and access controls, least-privilege principles, data classification, logging, monitoring, red teaming, human-in-the-loop controls, secure agent orchestration, runtime monitoring, and responsible AI governance.
• Proficiency in scripting and automation using Python, Bash, PowerShell, or similar technologies to support security monitoring, control validation, automated enforcement, and operational efficiency.

Preferred Qualifications

• Experience implementing security for large-scale AI projects in cloud-native or hybrid environments, including AWS, Azure, or Google Cloud, with knowledge of AI governance, security posture management, data security posture management, ethical frameworks, and responsible AI principles.
• Bachelor’s degree in Computer Science, Information Technology, Cybersecurity, or a related field.
• Relevant certifications such as CISSP, CISM, GIAC, or cloud security certifications are a plus.

Travel

Ability to travel globally around 15% to 20% of the time, including overnight stays.

Pay

The annual salary range for this role is $175,000 - $200,000. This job is also eligible for bonus/incentive pay.

Benefits

We offer a comprehensive package of benefits, including paid time off, medical/dental/vision insurance, and a 401(k), to eligible employees.