Pr. Associate Scientist/Scientist I, Analytical Development

About the role

The Principal Associate Scientist/Scientist I will support the Analytical Development Molecular Biology team at Solid Biosciences, a precision genetic medicine company focused on rare neuromuscular and cardiac diseases.

Responsibilities

• Provide technical expertise on different aspects of analytical development, including identifying new technologies, assessing Critical Quality Attributes (CQAs), process-related and product-related impurities, and executing methods for characterization of final drug substance/ product (DS/DP).
• Develop, optimize, and qualify molecular characterization methods to support the Solid Biosciences gene therapy portfolio.
• Perform and coordinate routine and non-routine analytical testing in support of internal Process Development and Vector Core teams as well as cGMP product characterization.
• Provide analytical support to QC/CMOs/CTOs not limited to technology transfer, method feasibility, optimization, qualification, troubleshooting, data trending, document review, and reporting.
• Compile, analyze, and present data findings to cross functional teams and senior leadership.
• Author and review SOPs, development reports, and documents to support regulatory submissions.
• Manage laboratory equipment and critical reagents inventory.
• Maintain accurate and well-documented analytical records including electronic laboratory notebooks (ELN).
• Mentor and train junior scientists and/or new team members.
• Perform additional duties and contribute to ad hoc projects as required.

Requirements

• Bachelor’s degree in Molecular Biology, Biochemistry, Genetics or related field and 6-8+ years’ experience in analytical development within a biotech/pharmaceutical and/or Quality Control environment required or MS with 4-6+ years of experience or Ph.D. with 0-2+ years of experience.
• Deep expertise in molecular biology complemented by extensive hands-on experience in long-read next generation sequencing (NGS) workflows, integrating wet-lab execution with analysis and interpretation of complex sequencing datasets.
• In-depth understanding of molecular techniques such as qPCR, ddPCR, and ELISA.
• Familiarity with relevant analytical / statistical software suites, not limited to Benchling, QX Manager, AccuSEQ, GraphPad Prism, and Softmax Pro.
• Good understanding of GxP compliance including regulatory requirements and trends related to product quality.
• Excellent critical thinking, technical, communication, and organizational skills required.
• Must be a team player willing to embrace an interactive team-based culture.

Compensation

The base compensation range for this role is: $110,000.00 - $135,000.00 Base salary offered is determined through an internal analysis utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity. Regular employees are eligible to receive both short-term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward individual performance and align incentives to Solid’s long term company performance.

Benefits

• Competitive Health and Dental programs with flexible plan offerings, including FSA and HSA programs
• 401(k) program participation with competitive company matched contributions
• Eligibility to participate in Solid’s Employee Stock Purchase Plan
• Mobile phone subsidy for eligible employees
• Tuition Reimbursement
• Vision Coverage
• Life Insurance
• Voluntary Pet Insurance
• Employee Discount Program on Travel, Entertainment, and Services
• Employee Assistance Programs
• Daily Subsidized Lunch Delivery (onsite @ Hood Park)
• Free Onsite Full-Service Gym (onsite @ Hood Park)
• Employee Parking (onsite @ Hood Park)
• 12 Observed Holidays and a winter shut down
• 15-day PTO Policy and a 80-hour rollover YoY
• 40-hour Sick Policy
• 8 Hour Floating Holiday