Postdoctoral Scientist - O'Brown Lab

About the role

We are seeking a highly motivated and independent Postdoctoral Scientist to join our in-person, cross-disciplinary team. This role focuses on understanding the developmental and cellular mechanisms that regulate blood-brain barrier function using zebrafish and mouse models. Projects aim to define how vascular and surrounding neuronal and glial cells interact during development, how these interactions are disrupted in disease, and how those insights can guide translational research.

What You’ll Get

• Close mentorship from Dr. O’Brown and the opportunity to mentor junior trainees.
• A focus on career development, with support for producing publications.
• Active guidance for both academic and industry career pathways — BBB research is highly applicable to both.
• Ongoing networking support, including conferences and collaboration opportunities.
• The opportunity to shape the direction of a growing, high-impact lab working at the intersection of development and neurovascular biology.

What you will do

• Lead independent research projects focused on vascular biology and BBB development.
• Conduct experiments in zebrafish and mouse models, including microinjections, live imaging, and behavioral studies.
• Apply molecular biology techniques including PCR, cloning, and genotyping.
• Perform in vivo imaging and high-resolution microscopy to visualize vascular function and BBB dynamics.
• Analyze or support RNA sequencing experiments.
• Supervise undergraduate trainees and contribute to an open, collaborative lab culture.
• Document and present findings in internal meetings and scientific publications.

What You Bring

• A Ph.D. in Developmental Biology, Molecular Biosciences, or a related field (e.g., Genetics, Systems Biology).
• Prior experience with in vivo techniques, ideally in zebrafish (preferred) or mouse models.
• Hands-on skills in vascular biology, developmental imaging, and/or blood-brain barrier research.
• Experience with RNA sequencing workflows, data interpretation, or collaboration with sequencing teams.
• Proficiency in molecular biology techniques such as cloning, PCR, and genotyping.
• A strong sense of independence, with the ability to manage and lead scientific projects autonomously.

Physical Requirements

Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace.

Compensation And Benefits

Our employees are compensated from a total rewards perspective in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, time off, and a range of recognition and wellness programs. Visit our Benefits at HHMI site to learn more.

Compensation Range: $70,000.00 (minimum) - $80,500.00 (midpoint) - $91,000.00 (maximum)

Pay Type: Annual

HHMI’s salary structure is developed based on relevant job market data. HHMI considers a candidate's education, previous experiences, knowledge, skills and abilities, as well as internal consistency when making job offers. Typically, a new hire for this position in this location is compensated between the minimum and the midpoint of the salary range.

HHMI is an Equal Opportunity Employer

We use E-Verify to confirm the identity and employment eligibility of all new hires.