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Postdoctoral Scientist - Lysosomal Biology & Neuroprotective Mechanisms

BioSpace · Boston, MA · 1 mo ago
Information Technology$58k–$123k/yrFull-time
We need to output HTML fragment with sections for headings: About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule. Only include sections that have real specific content. We must not repeat job title. Must not include Job ID etc. Remove boilerplate. Must preserve all substantive info. We need to parse the posting. Key parts: - Intro paragraph about Lilly: "At Lilly, the work is demanding because patients are waiting..." etc. This is about the company, maybe "About the role"? Actually "About the role" heading is for description of role. The intro is more about company mission. Could be placed under "About the role" or maybe we can have a section "About the role" containing that description plus role specifics. The posting includes: "Eli Lilly and Company is seeking a highly motivated Postdoctoral Scientist to join the Lilly Gene Therapy (LGT) organization, with a primary focus on lysosomal biology and its role in metabolic regulation and cellular protection. This role will investigate how the lysosome senses and adapts to shifting metabolic states — e.g., chronic inflammation, obesity, and pulmonary disease — and how restoration of lysosomal function confers protection against metabolic dysfunction and neurodegeneration, using multi-omics bioanalytical approaches across peripheral and CNS tissues. The successful candidate will bring deep expertise in LC-MS–based lipidomics, metabolomics, and proteomics profiling, and in combination with transcriptomic and immunoproteomic/ligand-binding platforms will bring deeper understanding on the interactions between metabolic state and lysosomal health. This position offers hands-on involvement in preclinical mouse studies, collaboration with internal cross-functional teams, and scientific oversight of external CRO-led studies. This postdoctoral role offers a unique opportunity to define the molecular mechanisms linking lysosomal-metabolic regulation to chronic inflammatory disease and neuroprotection within a leading pharmaceutical research organization. The position provides high-impact scientific exposure, cross-functional collaboration, and skill development at the intersection of lysosomal biology, multi-omics analytics, and translational biomarker science. Publication in peer-reviewed journals is expected." That's a good block for "About the role". Then "Key Responsibilities" with bullet list (multiple paragraphs). We'll convert each bullet line into
  • . The bullet lines start with headings like "Multi-Omics Bioanalysis of Lysosomal & Metabolic Function", then sentences. We'll treat each bullet as a list item. Then "Basic Requirements" list. Then "Additional Skills/Preferences" maybe under Skills. Then "Other Information": includes fixed-term role for two years, extendable up to four years, eligibility to apply for full-time positions upon completion. This is about contract duration, maybe under "Schedule"? Actually schedule is about work schedule (daily on-site presence). The posting says: "This position is based out of the Boston, MA Lilly location, and requires daily, on-site presence and lab work, with opportunities for scientific exchange..." That's schedule info (daily on-site). Also "fixed-term role for two years, extendable up to four years" maybe under "Schedule"? Could be under "Schedule" as duration. But we have separate sections: Benefits, Pay, Schedule. We need to include Pay and Benefits if present. Pay: "Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $58,000 - $123,200 Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance)." That's pay info. So we need a Pay section. Benefits: "In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)." That's benefits. Schedule: The posting mentions "requires daily, on-site presence and lab work". Also "fixed-term role for two years, extendable up to four years". Could be schedule (duration and location). We'll include schedule section with that info. We also have "Other Information" includes EEO etc which we must remove (boilerplate). Also accommodation request etc remove. Also ERGs list remove. Also "#WeAreLilly" remove. We must not invent or summarize away detail. Must preserve all substantive info. So we need to include all the substantive content from the posting, except boilerplate. We need to ensure we don't leave any heading with empty content. So we will include sections: About the role, Responsibilities, Requirements, Qualifications? Actually we have Basic Requirements (which could be Requirements). Also Additional Skills/Preferences could be Skills. Qualifications maybe same as Requirements? The instruction says use headings like About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule. We can map: - About the role: intro paragraph + role description. - Responsibilities: the Key Responsibilities block. - Requirements: Basic Requirements. - Qualifications: maybe we could combine with Requirements? But we need to avoid empty headings. If we don't have separate qualifications content, we could omit Qualifications heading. The instruction: "Prefer a few substantive sections over many thin ones." So we can omit Qualifications if not distinct. We'll include Requirements and Skills. - Skills: Additional Skills/Preferences. - Benefits: benefits paragraph. - Pay: compensation paragraph. - Schedule: fixed-term duration and daily on-site presence. We also have location info (Boston, MA) which could be part of Schedule or About the role. We'll put in Schedule. Now we need to format: Use

    for section headings. Use
    • for any list of duties/requirements/benefits, and

      for prose. Thus each section:

      About the role

      then

      ...

      . For Responsibilities:

      Responsibilities

      then
        with
      • items. For Requirements:

        Requirements

        then
          . For Skills:

          Skills

          then
            . For Benefits:

            Benefits

            then
              (list each benefit). For Pay:

              Pay

              then

              . For Schedule:

              Schedule

              then

              . We must preserve all substantive info. Let's extract details. About the role prose: combine the introductory paragraph about Lilly and the role description. Let's craft a single paragraph that includes all that info without omitting. Original intro: "At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us." Then role specifics: "Eli Lilly and Company is seeking a highly motivated Postdoctoral Scientist to join the Lilly Gene Therapy (LGT) organization, with a primary focus on lysosomal biology and its role in metabolic regulation and cellular protection. This role will investigate how the lysosome senses and adapts to shifting metabolic states — e.g., chronic inflammation, obesity, and pulmonary disease — and how restoration of lysosomal function confers protection against metabolic dysfunction and neurodegeneration, using multi-omics bioanalytical approaches across peripheral and CNS tissues. The successful candidate will bring deep expertise in LC-MS–based lipidomics, metabolomics, and proteomics profiling, and in combination with transcriptomic and immunoproteomic/ligand-binding platforms will bring deeper understanding on the interactions between metabolic state and lysosomal health. This position offers hands-on involvement in preclinical mouse studies, collaboration with internal cross-functional teams, and scientific oversight of external CRO-led studies. This postdoctoral role offers a unique opportunity to define the molecular mechanisms linking lysosomal-metabolic regulation to chronic inflammatory disease and neuroprotection within a leading pharmaceutical research organization. The position provides high-impact scientific exposure, cross-functional collaboration, and skill development at the intersection of lysosomal biology, multi-omics analytics, and translational biomarker science. Publication in peer-reviewed journals is expected." We'll combine into one paragraph (maybe two paragraphs but we can keep as one

              with line breaks? Better to keep as one

              but could be long; still okay. Now Responsibilities: The bullet list: - Multi-Omics Bioanalysis of Lysosomal & Metabolic Function Lead the design, development, optimization, and execution of LC-MS–based, immunoproteomics, and ligand-binding (LBA) assays to quantify biomarkers of lysosomal health and degradative capacity, across peripheral, pulmonary, and CNS tissues. Generate and interpret data to characterize modules governing autophagy, cargo receptors, lysosomal biogenesis, and lysosomal lipid metabolism. Perform cross-validation of key hits in various in vitro and in vivo system. - Mechanistic Pathway Analysis Develop and apply working knowledge of the lysosomal pathway and its metabolic regulatory circuits to interpret generated data in a mechanistic and therapeutic context, with a focus on lysosomal biogenesis and nutrient-sensing signatures. Integrate lipidomic, proteomic, and transcriptomic readouts into an integrated "lysosomal health and degradation capacity" framework applicable across tissues, including lung and brain. Contribute mechanistic interpretation linking lysosomal lipid and pathway-level findings to protective mechanisms in chronic inflammation, including neurodegeneration and pulmonary disease. - In Vivo Study Design & Model-Based Investigation Collaborating with extended research team to design and execution in vivo and in vitro studies to characterize the role of lysosomal homeostasis in metabolic status, chronic inflammation and neurodegeneration. Apply sound experimental design principles; diagnose and troubleshoot complex technical challenges related to assay performance, tissue processing, or data variability. - Translational Biomarker Development Identify peripheral and tissue-specific biomarkers and explore their clinical relevance. Support validation of key lipid and protein markers against available human biofluid datasets to strengthen translational rationale for future clinical studies. Maintain meticulous experimental documentation, ensuring clear traceability, data integrity, and compliance with LGT proven methods. - Data Analysis, Visualization, and Team Communication Apply proven methods for lipidomic, proteomic, and transcriptomic datasets generated from in vitro and in vivo studies and collaborate effectively with the extended team, including biostats for rigorous multi-dimensional analysis. Generate clear, insightful data visualizations to support project teams and decision-making forums. Communicate findings effectively through presentations, written summaries, and peer-reviewed publications. Actively contribute as a proactive, team-oriented scientist within a highly collaborative LGT research environment. We need to turn each bullet heading and its subpoints into list items? The instruction: Use

              • for any list of duties/requirements/benefits. So each duty can be a list item. Could combine multiple sentences into one
              • . We'll make each major duty as a list item containing the heading and its subpoints as sentences. Thus we will have 5
              • items. Now Requirements (Basic Requirements): - PhD in Biochemistry, Neuroscience, Molecular Biology, Cell Biology, or a closely related life sciences field. - Demonstrated in-depth experience with LC-MS/MS-based lipidomics, metabolomics, and/or proteomics assay development and quantification. - Experience with immunoproteomic, ELISA, or ligand-binding assay (LBA) techniques, and PCR/qPCR/ddPCR for transcript quantification. - Qualified applicants must be authorized to work in the United States on a full-time basis. - Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1,

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