Postdoctoral Scientist- Bardwell Lab

Primary Work Address: 4544 MSRB II, Dock #6, Ann Arbor, MI, 48109-0650

About the Role

The Bardwell lab at the University of Michigan is studying how cellular factors regulate protein homeostasis and RNA structure, and how defects in these processes contribute to neurodegenerative disease. Our research focuses on proteins implicated in neurological disorders, including SERF family microproteins, the microtubule-associated protein tau, and the ALS-linked RNA-binding protein TDP-43. In particular, the lab's work focuses on how ribonucleoproteins affect the formation of non-canonical RNA structures called G4-quadruplexes, which are involved in chromatin structure, protein folding, and amyloid formation linked to neurological diseases. Our research integrates genetic, molecular, cellular biology, and structural biophysics to inform both basic biology and future therapeutic applications. For more information, visit the Bardwell Lab website.

We are seeking a highly motivated and independent Postdoctoral Scientist to join our in-person, cross-disciplinary team. This role focuses on understanding the role of RNA-binding proteins, including microproteins, using cell biological and NMR approaches. Projects aim to define how these proteins interact with RNA to affect its structure, how these interactions are disrupted in disease, and how those insights can guide translational research.

Responsibilities

• Lead independent research projects focused on chromatin and RNA structure.
• Apply molecular biology techniques including PCR, cloning, and genotyping.
• Perform in vivo high-resolution microscopy to visualize protein and RNA localization.
• Apply structural biological approaches including NMR spectroscopy.
• Supervise undergraduate trainees and foster an open, collaborative lab culture.
• Document, analyze, and present findings at internal meetings and in scientific publications.

Requirements

• A Ph.D. in Molecular Biosciences, Genetics, Chemistry, Biophysics, or a closely related field.
• Hands-on expertise in biochemistry, biophysical, or cell biological research.
• Proficiency in molecular biology techniques such as cloning and PCR.
• Prior experience researching non-canonical RNA structures (like G4-quadruplexes), chromatin organization, or neurodegenerative disease models.
• A strong sense of scientific independence, with the proven ability to manage and lead scientific projects autonomously.

Benefits

• Close mentorship from Dr. Bardwell and opportunities to mentor junior trainees.
• A focus on career development, with support for producing publications.
• Expert training on scientific communication, including manuscript preparation and oral presentation of findings.
• Active guidance for both academic and industry career pathways.
• Robust networking support, including conferences and collaboration opportunities.
• The opportunity to shape the direction of a high-impact lab working at the intersection of biophysics and genetics.
• Competitive pay, exceptional health benefits, retirement plans, time off, and a range of recognition and wellness programs. Visit HHMI Benefits to learn more.

Pay

Hiring pay range: $70,000.00 - $80,500.00 per year.

Physical Requirements

• Remaining in a normal seated or standing position for extended periods of time.
• Reaching and grasping by extending hand(s) or arm(s).
• Dexterity to manipulate objects with fingers, for example using a keyboard.
• Communication skills using the spoken word.
• Ability to see and hear within normal parameters.
• Ability to move about the workspace, including moving materials weighing up to several pounds (such as a laptop computer or tablet).

Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis.