Postdoctoral Fellow, Dr. Ian Guldner
About the role
The Guldner Laboratory at the Salk Institute for Biological Studies is seeking a highly motivated and creative Postdoctoral Fellow to investigate the cellular and molecular mechanisms that regulate brain aging, neurodegeneration, and intercellular communication. The lab seeks to understand how cells communicate through the exchange of proteins and how these communication networks change with age and disease. The laboratory combines cell-specific proteome tagging, advanced cell isolation approaches, in vivo models, proteomics, and genetic and pharmacologic perturbations to identify proteins transferred between cell types and determine how these interactions influence tissue function, aging, and disease. A major focus is understanding communication between brain cells and how age-related changes in proteostasis contribute to cognitive decline and neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. The successful candidate will have the opportunity to develop and lead a research project at the intersection of aging biology, neuroscience, proteostasis, neuroimmunology, and neurodegeneration. Projects will address how proteostasis and cellular communication change with aging and/or disease and the implications of these changes on brain health on scales ranging from molecules to cells to organismal behavior. The ideal candidate will be intellectually curious, creative, and passionate to pursue fundamental biological questions both collaboratively and with a high degree of independence.
Responsibilities
- Design, conduct, and analyze original research projects both independently and collaboratively.
- Develop and implement experimental approaches to address scientific questions.
- Interpret and communicate research findings through publications, presentations, and scientific meetings.
- Collaborate with faculty, staff scientists, postdoctoral researchers, students,