Post-Doctoral Research Fellow – HBV Biomarkers and Liquid Biopsy

Key Responsibilities

• Perform bioinformatic and statistical analyses of NGS data, including detection and characterization of HBV–host junction sequences (HBV-JS)
• Develop and maintain computational pipelines for circulating tumor DNA (ctDNA) and viral genomic analysis
• Integrate genomic, clinical, and imaging datasets to support biomarker development and validation
• Contribute to study design, data interpretation, manuscript preparation, and grant reporting
• Collaborate with multidisciplinary teams across MGH and partner institutions

Wet Lab Responsibilities (optional)

• Participate in molecular laboratory activities, including DNA extraction, qPCR, and NGS library preparation, as appropriate
• Support assay optimization and validation efforts in collaboration with BSBI and MGH laboratories
• Gain exposure to experimental workflows supporting translational biomarker development

Qualifications

• Education: PhD, MD, or equivalent in bioinformatics, computational biology, molecular biology, biomedical sciences, or a related field
• Experience In One Or More Of The Following: Next-generation sequencing (NGS) data analysis, Bioinformatics or computational biology, Cancer genomics, virology, or molecular diagnostics
• Proficiency in programming languages such as Python, R, or equivalent
• Strong analytical, organizational, and communication skills

Preferred Qualifications

• Experience in liquid biopsy, circulating DNA analysis, or viral genomics
• Familiarity with clinical datasets and translational research
• Experience with molecular biology techniques (PCR, sequencing)
• Interest in bridging computational and experimental approaches