Post Doctoral Fellow, Stem Cell Lab (IPSC)

Key Roles/Responsibilities

• Design and independently conduct innovative research investigating the metabolic regulation of human stem cell fate, lineage specification, differentiation, and tissue maturation using human induced pluripotent stem cell (iPSC)-derived models.
• Develop, optimize, and characterize human iPSC reprogramming, maintenance, genome editing, directed differentiation, and organoid culture systems for applications in regenerative medicine and disease modeling.
• Design and implement metabolic profiling approaches, including mitochondrial functional assays, extracellular flux analysis, metabolomics, stable isotope tracing, and complementary molecular and cellular approaches to define mechanisms regulating stem cell biology.
• Integrate transcriptomic, proteomic, metabolomic, imaging, and functional datasets to identify pathways governing stem cell fate and tissue maturation.
• Collaborate with multidisciplinary investigators across the NIH Standardized Organoid Modeling (SOM) Initiative to develop reproducible, scalable, and physiologically relevant stem cell and organoid platforms.
• Publish research findings in peer-reviewed journals and present results at national and international scientific meetings.
• Contribute to grant applications, technical reports, manuscripts, and collaborative research initiatives.
• Contribute to the development and implementation of new experimental approaches and technologies that advance the mission of the Stem Cell Laboratory and the SOM Initiative.

Basic Qualifications

• Possession of a doctorate degree from an accredited college or university according to the Council for Higher Education Accreditation (CHEA).
• No work experience required with a Doctorate degree.
• Experience in mammalian cell culture and aseptic technique.
• Demonstrated experience designing and independently executing scientific research projects.
• Experience with molecular and cellular biology techniques.
• Evidence of scientific productivity through peer-reviewed publications.
• Must possess basic Microsoft Office skills.
• Able to obtain and maintain a security clearance.

Preferred Qualifications

• Experience with human iPSC reprogramming, culture, characterization, genome editing, and directed differentiation.
• Experience with organoid culture and advanced 3D cell culture systems.
• Research experience in stem cell metabolism, mitochondrial biology, bioenergetics, or metabolic regulation of cell fate.
• Experience with Seahorse extracellular flux analysis, metabolomics, stable isotope tracing, mitochondrial functional assays, or other metabolic phenotyping approaches.
• Experience with CRISPR/Cas9 genome engineering.
• Experience with single-cell RNA sequencing, spatial transcriptomics, epigenomics, or other multi-omics approaches.
• Experience with advanced microscopy, flow cytometry, or high-content imaging.
• Demonstrated ability to work effectively within multidisciplinary collaborative research teams.
• Strong written and verbal communication skills.