Post-Doc Research Associate - Brouwer Lab

Position Summary

A postdoctoral research position is available immediately to investigate the utility of in vitro models (e.g., hepatic organoid 3D cell models, sandwich-cultured hepatocytes, HuH-7 cells, membrane vesicle systems) to (1) predict the hepatic disposition of drugs and metabolites in vivo, (2) predict the impact of disease-mediated alterations in transport function on hepatocellular accumulation and routes of excretion (canalicular vs. basolateral) of anionic drugs/metabolites, and (3) examine hepatic transporter trafficking and regulatory mechanisms.

NIH-funded research program to study the hepatic disposition of xenobiotics utilizing in vitro model systems, regulation/trafficking of transport proteins, and cellular/molecular mechanisms responsible for hepatic structure and function.

• Research includes but is not limited to: in vitro cell culture experiments, transport assays, Western Blotting, cloning and mutagenesis, immunohistochemical imaging and live cell imaging, LC-MS/MS, maintaining the laboratory’s animal care and use and radiation safety records in accordance with institutional, state, and federal guidelines.

Minimum Education And Experience Requirements

• Ph.D. in cell/molecular biology, biochemistry, pharmacology, pharmaceutics, engineering or related discipline.
• Experience with cell culture and advanced molecular biology/biochemistry techniques.
• Excellent communication skills and ability to work independently as well as a member of an interdisciplinary team are essential.

Special Physical/Mental Requirements

Position will require some night and weekend bench and manuscript work. Position includes exposure to lab animals, human hepatocytes, adenoviral vector, and radiolabeled BSL -2 compounds.