Post Doc - Immunology

About the role

The role involves contributing to a high-visibility research program at the intersection of cellular senescence biology, fibrosis, and immune-based therapeutics. The goal is to establish a precision senolytic approach that selectively eliminates pathological senescent cells in the fibrotic lung while sparing healthy tissue.

Responsibilities

• Establish and characterize models of cellular senescence relevant to fibrotic lung disease, spanning primary human cells, iPSC-derived cells, and in vivo fibrosis models.
• Identify and validate cell-surface markers that distinguish pathological senescent cells from healthy tissue, prioritizing candidates with a favorable safety profile.
• Develop and engineer immune effector–based strategies to selectively eliminate senescent cells in the fibrotic lung.
• Evaluate senolytic efficacy and its impact on fibrosis across disease-relevant human tissue and in vivo models.
• Collaborate with cross-functional teams and external academic partners, present findings at major scientific conferences, and publish as first author.

Requirements

• PhD in Immunology, Cell Biology, Molecular Biology, Aging Biology, or a closely related field.
• Demonstrated experience with cellular senescence and at least one of the following: fibrosis, aging biology, immunology, therapeutic modality engineering (e.g., cell therapy, antibody, or protein engineering), or relevant analytical approaches such as proteomics or single-cell analysis.
• Strong publication record demonstrating scientific productivity and independence.

Qualifications

• Basic qualifications include being authorized to work in the United States on a full-time basis.
• Additional qualifications include self-directed and highly motivated individual who wants to learn new techniques while continually pursuing research and publication goals, excellent communicator (oral and written) with presentation experience, along with a strong publication record, interest in cellular senescence, fibrosis biology, and translational drug discovery, background in cellular senescence or aging biology, including relevant cellular and in vivo models, hands-on expertise in immunology and immune cell biology, experience with therapeutic modality development, such as cell therapy, antibody, or protein engineering, familiarity with proteomic, transcriptomic, and/or high-parameter single-cell and imaging approaches, experience with human iPSC culture and directed differentiation, familiarity with disease-relevant human tissue and/or in vivo fibrosis models, strong analytical skills and the ability to integrate multi-modal datasets.

Skills/Preferences

• Self-directed and highly motivated individual who wants to learn new techniques while continually pursuing research and publication goals.
• Excellent communicator (oral and written) with presentation experience, along with a strong publication record.
• Interest in cellular senescence, fibrosis biology, and translational drug discovery.
• Background in cellular senescence or aging biology, including relevant cellular and in vivo models.
• Hands-on expertise in immunology and immune cell biology.
• Experience with therapeutic modality development, such as cell therapy, antibody, or protein engineering.
• Familiarity with proteomic, transcriptomic, and/or high-parameter single-cell and imaging approaches.
• Experience with human iPSC culture and directed differentiation.
• Familiarity with disease-relevant human tissue and/or in vivo fibrosis models.
• Strong analytical skills and the ability to integrate multi-modal datasets.

Pay

$58,000 - $123,200

Schedule

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance).

Benefits

• Ineligible for relocation assistance.
• Eligible for medical, dental, vision and prescription drug benefits.
• Eligible for a company-sponsored 401(k).
• Eligible for a pension plan.
• Eligible for vacation benefits.
• Eligible for flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts).
• Eligible for life insurance and death benefits.
• Eligible for certain time off and leave of absence benefits.
• Eligible for well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).