Pillar Therapeutics- Principal Scientist, Analytical Chemistry

About the role

We are in the discovery stage and will invest heavily in our emerging platform for oligonucleotide delivery. Our disease focus offers strong translatability from animal models to humans, providing a potentially rapid and efficient path to the clinic. Given our recent funding and commitment to building a first-in-class platform with clear therapeutic targets and indications, we are recruiting a Principal Scientist, Analytical Chemistry.

Responsibilities

• Define and implement reproducible analytical protocols to characterize oligonucleotides for biological evaluation in our targeted delivery platform
• Develop and implement QC methods to determine purity, composition, and concentration of oligonucleotides and conjugates using a toolbox of analytical methods (HPLC, MS, (bio)analytical assays, etc.)
• Develop and implement analytical methods (e.g., MS) to determine drug-to-conjugate ratios of antibody-oligonucleotide conjugates
• Develop and implement analytical methods to determine in vitro stability (e.g., serum stability) of oligonucleotides and conjugates
• In conjunction with the biology group, assist in development and implementation of analytical methods to determine pharmacokinetics and distribution of oligonucleotides and conjugates in vivo
• Assist in internal lab build, procuring and utilizing analytical equipment to characterize oligonucleotides and antibody/peptide-oligonucleotide conjugates
• Assist conjugation scientists in developing methods (SEC, IEX, etc.) to purify oligonucleotide conjugates

Requirements

• PhD. in chemistry or related discipline with 6+ years of experience working with oligonucleotide therapeutics (siRNA, ASOs, etc.) in the biopharmaceutical industry; or BS/MS with 10+
• Ideal candidate will have experience analyzing peptide-, protein-, or antibody-oligonucleotide conjugates, effectively operating in a cross-functional, collaborative environment
• Adept in state-of-the-art analytical methods (SEC, IEX, RP-HPLC, MS, etc.) to characterize oligonucleotide conjugates
• Experience in (bio)analytical assays to determine pharmacokinetic, distribution, and PD profiles of oligonucleotide therapeutics is a plus
• Demonstrate strong technical skills, with a robust attention to detail to ensure rigorous and demonstrable results

Qualifications

• Highly collaborative, intellectually curious, driven, trustworthy, humble, adaptable, and flexible
• Highly organized, thoughtful, and bring sound judgement and technical decision-making abilities
• Based on-site at the company’s headquarters in Cambridge, MA

Pay

The base salary range reflects our good faith estimate at the time of posting. Final compensation will depend on factors like experience, skills, and location. The role may also be eligible for an annual bonus and long-term incentives. Compensation and benefits may be updated in the future.

Salary base range: $160,000 - $190,000 USD