Pharmacovigilance Medical Director

About the role

Beeline Medicines is a clinical-stage biotechnology company focused on developing and delivering category-leading precision therapies to transform the lives of people living with autoimmune and inflammatory diseases. The company is developing medicines that have the opportunity to provide durable, life-changing impact, led by an established executive team and backed by world-class life science investors.

Essential Duties and Responsibilities

• Serve as the senior medical expert and physician for safety science and pharmacovigilance activities, providing authoritative medical judgment on individual case safety reports (ICSRs), aggregate safety analyses, signal evaluations, and benefit-risk assessments across the I&I portfolio.
• Lead the medical review and clinical data interpretation of safety data arising from clinical trials, spontaneous reports, literature, and real-world sources, ensuring timely, accurate, and scientifically rigorous assessment of all pharmacovigilance data.
• Direct the development and continuous maintenance of the company's benefit-risk framework, providing medical leadership in benefit-risk evaluations for regulatory submissions, label updates, and Health Authority safety communications.
• Lead the discussion at the company's Safety surveillance governance, providing medical and strategic direction on safety signal management, escalation procedures, and corrective action planning.
• Oversee the medical content and scientific quality of all aggregate safety reports, and regulatory submission dossiers for safety content.
• Partner with Clinical Development on the medical oversight of Data Safety Monitoring Board (DSMB) activities, clinical trial safety monitoring plans, safety risk mitigation plans (e.g., stopping rules), and protocol-level safety sections for all active and planned studies.
• Provide expert medical input to Risk management plans and relevant regulatory documents through the developmental cycle of the programs, and risk minimization measure design, execution, and effectiveness assessment.
• Provide medical leadership and scientific mentorship to the Pharmacovigilance team, including PV Scientists, and other functions (e.g., Medical Writers, and Operations personnel) establishing a culture of medical excellence and patient-first decision-making.

Qualifications

• Education: Medical degree (MD or DO) required; board certification or eligibility in immunology, rheumatology, internal medicine, or a relevant specialty experience in autoimmune disease is strongly preferred.
• Minimum of 5 years of combined clinical and pharmaceutical/biotech industry experience, with at least 2-3 years of dedicated pharmacovigilance or drug safety experience preferred.
• Demonstrated expertise serving as a physician-of-record for pharmacovigilance programs, including ICSR medical review, signal evaluation, benefit-risk assessment, and aggregate safety reporting.
• Deep knowledge of global safety and pharmacovigilance regulations including FDA guidance, EU GVP Modules I–XVI and ICH guidelines.
• Extensive experience providing medical leadership for safety surveillance plan, and benefit-risk assessment, and submissions for IND and NDA/BLA, as well as direct authorship or oversight of complex safety narratives for regulatory submissions.
• Proven experience engaging with global Health Authorities on pharmacovigilance topics, including regulatory meeting preparation, written responses to safety queries, and inspection support.
• Demonstrated ability to lead or participate in DSMB oversight, clinical trial safety monitoring, and safety governance committee activities at the sponsor level.
• Experience contributing to Risk Management Plans (RMPs) and REMS programs, including development of risk minimization measures and assessment of effectiveness.
• Demonstrated ability to lead, mentor, and develop cross-functional teams in a fast-paced, resource-constrained biotech or pharmaceutical environment; fosters a culture of accountability, inclusion, and continuous learning.
• Skilled at preparing and delivering compelling presentations, briefing documents and regulatory responses, and strategic updates to cross-functional leadership teams and board-level stakeholders.
• Adept at facilitating productive discussions in high-stakes meetings, interactions with regulators, and multi-party collaborations; balances clarity, diplomacy, and scientific precision.

Pay

The expected salary range for this position varies by location and will be communicated based on the country or region in which the selected candidate is hired. Actual pay will be determined based on experience, qualifications, location, and other job-related factors permitted by applicable local law. A discretionary annual bonus and long-term incentive award (e.g., equity) may be available based on individual and Company performance.

Salary Range: $266,000 - $344,000 USD

Benefits

We offer a comprehensive benefits package tailored to the country and region in which you are hired, in compliance with local laws and practices. Benefits may include, but are not limited to:

• Competitive health and wellness coverage (structure and premiums vary by country)
• Paid time off, public holidays, and additional leave entitlements in accordance with local requirements
• Flexible work arrangements / hybrid schedule

Equal Employment Opportunity

Beeline Medicines is an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity or expression, national origin, disability, age, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.

Reasonable Accommodation

If you require a reasonable accommodation to participate in the application or interview process, please contact careers@beelinemedicines.com to request an accommodation. We are committed to providing equal access to all candidates.

Privacy

Upon submission of this form I understand that Beeline Medicines is based in the United States and personal data submitted in the form will be transferred and accessed in the U.S. Information about Beeline Medicines privacy practices can be found at Privacy Policy - Beeline Medicines