Nuclear Magnetic Resonance Spectroscopist

About the role

The Nuclear Magnetic Resonance (NMR) Spectroscopist contractor provides analytical chemistry support for translational research, requiring expertise in solution-state NMR spectroscopy for small molecules and/or proteins.

Responsibilities

• Operate and maintain high-field NMR instruments (four 400 MHz and one 600 MHz spectrometers).
• Perform structural characterization, purity assessments, concentration and binding studies.
• Develop new NMR methods and prepare samples for analysis.
• Troubleshoot instrumentation, including performing weekly liquid nitrogen fills and quarterly helium fills of NMR magnets.
• Analyze and interpret spectral data from 1D, 2D, nD, and VT NMR experiments for structure verification, conformational analysis, chromatographic and isotopic purity analysis, and impurity identification.
• Utilize an in-house compound tracking system to enter and review data.
• Write papers, abstracts, summaries, reports, and presentations for publication in peer-reviewed journals.
• Perform both routine and specialized laboratory procedures of moderate to high complexity.
• Maintain current knowledge of NMR spectroscopy and associated instrumentation, providing subject matter expertise to collaborators.
• Assess, modify, and improve methods and procedures for experiments to meet specific needs.
• Maintain accurate records of experiments and evaluate results for validity and scientific meaning.
• Train staff on proper usage and maintenance of NMR spectrometers and mass spectrometry instrumentation.
• Develop and document new procedures and implement novel methods for NMR sample preparation and analysis, including automation and high-throughput technologies.
• Monitor and report safety issues and ensure proper retention of raw NMR data.
• Meet weekly with lab members to present updates.
• Perform and document activities supporting NMR spectroscopy operations, including instrument maintenance, equipment servicing, sample preparation, data acquisition, processing, analysis, and spectral interpretation.
• Generate and organize scientific data, figures, and tables; conduct literature reviews; and prepare technical reports, manuscripts, presentations, posters, and operational manuals.