Neurodegenerative Disease Senior Scientist

About the role

Parallel Squared Technology Institute (PTI) is a non-profit research institute focusing on developing technologies, reagents, and computational tools to enhance protein analysis, with a particular emphasis on single-cell proteomics. PTI applies these innovations to address societally relevant areas of biomedical research, including Alzheimer’s and related neurodegenerative diseases.

Responsibilities

• Design and execute research projects using single-cell proteomics to understand the molecular mechanisms of neurodegeneration in Alzheimer’s and related diseases.
• Computationally analyze large-scale, single-cell proteomic datasets to identify new molecular mechanisms of disease.
• Collaborate with external laboratories, brain banks, and tissue repositories on sample procurement.
• Prepare human brain tissue samples for proteomic analysis using methods and technologies developed at PTI.
• Help junior scientists gain expertise in experimental techniques used at PTI, analyzing and interpreting experimental results, recording data in laboratory notebooks, and writing up and presenting research results.
• Make regular presentations within PTI and to collaborators.
• Prepare manuscripts related to project outcomes and grant applications for external funding.
• Demonstrate a commitment to diversity, inclusion, and cultural awareness through actions, interactions, and communications with others.
• Other duties as assigned.

Qualifications

• PhD in Neuroscience or a related field.
• Direct, hands-on experience in preparing human brain tissue for downstream analyses.
• Direct, hands-on experience with single cell analysis.
• Excellent communication and interpersonal skills, record keeping ability, and attention to detail.

Preferred Qualifications

• Experience in high throughput or automated tissue sample collection, preparation, and analysis, particularly with human brains.
• Experience with mass spectrometry proteomics.
• Fluency in R or Python, particularly in the context of single-cell analysis.

Benefits

We offer an opportunity to change the world and work with some of the smartest and the most talented experts from different fields. We provide excellent medical, dental, and vision insurance with many $0 premium options for you and your family with several national and regional providers. Most employees have more than 20 plan options to choose from. Company-paid group life, AD&D, long- and short-term disability insurance, 15 days PTO + 10 sick days per year, 18 company holidays + your birthday off, $5,000 per year educational reimbursement, up to 16 weeks paid parental leave, and a salary range of $86,000 - $119,000 per year. We aim to help fill a structural gap in today's R&D system. We enable fundamental research that requires unusual levels of scale and coordination yet is not rapidly monetizable by industry. We're bringing together top talent from academia, industry, and startups to build a new model for innovative R&D. As an incubator within the Schmidt Futures Network, we identify high-impact scientific or technical research and development opportunities, ultimately defining and launching these projects as Focused Research Organizations. We are an Equal Employment Opportunity employer that proudly pursues and hires a diverse workforce. We do not make hiring or employment decisions on the basis of race, color, religion or religious belief, ethnic or national origin, nationality, sex, gender, gender-identity, sexual orientation, disability, age, military or veteran status, or any other characteristic protected by applicable local, state, or federal law or company policy. We strive for a healthy and safe workplace and strictly prohibit harassment of any kind. We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.