Manager, Clinical Supply Chain

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins, including daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, currently in clinical development.

About the role

The Manager serves as the clinical supply chain lead for assigned clinical studies, ensuring uninterrupted clinical trial supply. This position partners closely with Clinical Operations, product lead, Regulatory Affairs, Quality Assurance, Project Management, and external vendors to support the successful execution of global clinical studies while maintaining compliance, inspection readiness, and operational excellence.

Responsibilities

• Serve as the clinical supply lead for assigned study(s) and develop/manage the clinical supply.
• Develop and execute comprehensive clinical supply strategies for global clinical development programs from Phase I through Phase III, ensuring alignment with program objectives, enrollment assumptions, manufacturing timelines, and regulatory requirements.
• Lead demand forecasting, supply planning, inventory management, and scenario analysis to ensure continuous product availability while minimizing waste and supply risk.
• Execute global packaging, labeling, and distribution, ensuring compliance with country-specific requirements and efficient supply to clinical sites worldwide.
• Support IRT/RTSM systems, including development of user requirements, execution of user acceptance testing, implementation of supply strategies, change controls, and ongoing system maintenance.
• Review and approve clinical supply chain documentation including clinical label text, batch records, pharmacy manuals, and protocols.
• Support INDs, IMPDs, and other regulatory submissions as applicable.
• Facilitate vendor selection, qualification, contracting, and performance management activities for packaging vendors, depots, logistics providers, comparator sourcing vendors, and other external partners.
• Develop and implement risk management strategies to proactively identify and mitigate supply chain risks that could impact study timelines or patient enrollment.
• Represent Clinical Supply Chain on cross-functional program teams and governance committees, providing strategic recommendations and decision-making support.
• Develop and manage study-level clinical supply budgets, vendor forecasts, and operational expenditures.
• Facilitate continuous improvement initiatives and establish scalable processes, systems, and metrics to support organizational growth.
• Participate in authoring, reviewing, approving, and maintaining SOPs, work instructions, and business processes related to clinical supply chain operations.

Requirements

• Bachelor’s or Master’s degree in Supply Chain, Life Sciences, Pharmacy, Engineering, or a related scientific discipline with a minimum of five years of relevant pharmaceutical or biotechnology industry experience.
• Demonstrated experience managing global clinical supply chains supporting Phase I through Phase III clinical trials.
• Knowledge of clinical supply planning, forecasting, inventory management, packaging, labeling, distribution, and clinical logistics.
• Strong experience managing external vendors, depots, distribution centers, and logistics providers.
• Thorough understanding of GCP, GMP, GDP, ICH guidelines, and global regulatory requirements governing clinical trial materials.
• Strong leadership, communication, organizational, analytical, and project management skills, with experience working effectively across complex cross-functional organizations.
• Experience with IRT/RTSM systems, inventory management systems, ERP platforms, and clinical supply planning tools.

Preferred Qualifications

• Experience supporting oncology clinical development programs.
• Additional experience supporting late-stage development, comparator sourcing, combination therapy studies, commercial readiness activities, and global cold-chain distribution.
• Experience implementing clinical supply systems, driving process improvements, and leading or mentoring supply chain professionals in a growing biotechnology environment.

Pay

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is $143,000 - $178,000 USD. The range displayed is intended for an individual working onsite in Redwood City and will be adjusted for the local market. Base pay salary is determined by role, level, location, job-related skills, experience, market dynamics, and relevant education or training.

Benefits

Base pay salary range is one part of the overall total rewards program at Revolution Medicines, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.