Manager, Clinical Supply Chain

About the role

Centessa Pharmaceuticals, a wholly owned subsidiary of Eli Lilly and Company, is a clinical-stage company developing orexin receptor 2 (OX2R) agonists as a new class of medicines for the treatment of narcolepsy and potentially other sleep-wake disorders. Centessa's lead investigational candidate – cleminorexton (formerly ORX750) – is being developed for narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia. The OX2R agonist portfolio includes additional clinical and preclinical-stage assets with potential utility across a broader range of neurological, neurodegenerative, and neuropsychiatric conditions. Headquartered in Boston, Massachusetts, Centessa was recognized as a Great Place to Work® in 2026.

Centessa is seeking a Manager, Clinical Supply Chain to support end-to-end planning, execution, and maintenance of uninterrupted clinical supply — including investigational product (IP), comparators, and ancillary materials — across assigned clinical programs. This role ensures compliance with GxP requirements, study timelines, and budgets while partnering cross-functionally with Clinical Operations, CMC, Quality, Regulatory, Finance, and external vendors. Reporting to the Senior Director, Clinical Supply Chain, the individual will build strong relationships with internal teams and third-party suppliers to align objectives and support successful trial execution, with particular attention to clinical forecasts, inventory systems, and IRT tools.

Responsibilities

Clinical Supply Planning & Execution

• Contribute to the development and execution of clinical supply strategies for early- to mid-phase clinical trials (Phase 1–3 as applicable).
• Manage clinical supply plans, demand forecasts, and inventory strategies — including tracking through Interactive Response Technology (IRT) systems — in alignment with protocol requirements and enrollment projections.
• Support packaging, labeling, distribution, and resupply activities for investigational products and comparators.
• Ensure on-time delivery of clinical supplies to depots and clinical sites globally.

Vendor & CDMO Management

• Partner with Quality, Clinical, CMC, and external CDMOs to develop, review, and approve clinical labels, and support CDMO packaging/labeling schedules to ensure supply availability.
• Interact regularly with third-party providers to manage the logistics and licenses required to ship materials from manufacturing to bulk storage facilities, courier depots, and investigator sites.
• Collaborate with CMC and QA to facilitate the document transfer required for IP/QP release by CDMOs.

Quality & Compliance Support

• Monitor shelf-life and expiry dating, and coordinate retest/extension activities with the analytical team to ensure continuous supply.
• Manage the investigation, reporting, and communication of outcomes from temperature excursions and product complaints.
• Support product recovery activities pending investigation of IP from investigator sites, as needed.

Cross-Functional Collaboration & Representation

• Communicate effectively across functional areas, applying a solid working knowledge of clinical supply chain processes.
• Author Pharmacy Manuals for clinical studies, as needed.
• Represent Supply Chain in Clinical and CMC Sub-Team meetings.

Requirements

• Bachelor's degree in engineering or science required.
• 3–5 years of biotech/pharma industry experience in clinical supply chain, including international experience, required.
• Must be authorized to work in the United States on a full-time basis; Lilly will not provide support for or sponsor work authorization or visas (including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1).
• Working knowledge of clinical supply chain processes and GMP/GDP requirements.
• Experience coordinating cross-functional project teams and external vendors.
• Strong organizational, analytical, decision-making, and interpersonal skills, with excellent attention to detail.
• Ability to work independently in a fast-paced, dynamic environment.
• Demonstrated ability to coordinate CDMO activities supporting clinical development of pharmaceutical products.
• Ability to thrive in a small-company culture and contribute to creating and implementing processes.

Pay

The anticipated wage for this position is $105,000 – $169,400. Actual compensation will depend on a candidate's education, experience, skills, and geographic location. Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance).

Benefits

• Company-sponsored 401(k)
• Pension
• Vacation benefits
• Medical, dental, vision, and prescription drug benefits
• Flexible benefits (healthcare and/or dependent day care flexible spending accounts)
• Life insurance and death benefits
• Time off and leave of absence benefits
• Well-being benefits (employee assistance program, fitness benefits, employee clubs and activities)

Schedule

Full-time