Jobs · OTHR · Massachusetts

In Vivo Study Specialist

Parabilis Medicines · Cambridge, MA · 2 mo ago
On-siteOTHR$75k–$85k/yrFull-time

About the role

We are seeking a highly motivated In Vivo Study Specialist to join our In Vivo Pharmacology team and contribute to the preclinical evaluation of Helicon™ peptide therapeutics for oncology.

Responsibilities

  • Independently execute in vivo pharmacology studies supporting target validation, lead optimization, mechanism-of-action, and efficacy evaluation of Helicon therapeutics.
  • Perform mouse oncology studies using xenograft, syngeneic, patient-derived xenograft (PDX), and genetically engineered mouse models (GEMMs).
  • Conduct routine and advanced in vivo procedures with a high standard of technical precision, including:
    • Intravenous (IV), intraperitoneal (IP), subcutaneous (SC), and oral gavage (PO) dosing
    • Tumor cell implantation, caliper-based tumor measurement, and tumor growth monitoring
    • Serum blood collection and pharmacokinetic (PK) sampling via multiple routes
    • Body weight monitoring and clinical observations per IACUC-approved protocols
    • Terminal necropsy and systematic collection of tumor and tissue specimens for downstream analysis
    • Minor and major survival surgeries, including oncology-specific surgical procedures
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
  • Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target

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