Histotechnologist

About the role

We’re looking for a Histotechnologist to own and execute histology workflows at Nudge, focused primarily on mouse and rat brain tissue. You’ll be responsible for building the full histology pipeline: perfusion, prosection, embedding, sectioning, staining, and imaging — across both traditional and cutting-edge techniques, to understand the mechanisms of ultrasonic neuromodulation.

Responsibilities

• Perform routine and advanced histological processing of rodent brain tissue, including perfusion, prosection, fixation, embedding (paraffin and OCT), and sectioning via microtome, cryostat, and vibratome
• Execute standard histological stains (H&E, special stains) and immunohistochemistry using both manual and automated staining platforms
• Operate and optimize tissue clearing platforms (electrophoretic, solvent-based) for whole-brain and thick-section imaging
• Prepare cleared tissue for light sheet fluorescence microscopy and volumetric 3D imaging
• Operate and maintain automated sectioning and tissue processing systems
• Prepare and process samples for spatial omics platforms, including multiplexed protein imaging and spatial transcriptomics, with both RNA- and protein-based tagging approaches
• Develop, optimize, and document SOPs for histological workflows, ensuring reproducibility and quality
• Collaborate with research scientists to adapt tissue processing and staining strategies to specific experimental questions

Requirements

• At least 3 years of industry experience in histotechnology
• Hands-on experience in histotechnology, with significant time spent processing rodent brain tissue
• Proficiency across core histological techniques: microtomy (paraffin, cryo, vibratome), tissue embedding, H&E staining, and immunohistochemistry
• Experience with at least one tissue clearing method and associated imaging modalities (light sheet microscopy)
• Familiarity with automated staining and sectioning platforms

Qualifications

• HT(ASCP) certification or equivalent training
• Bachelor’s degree in biology, neuroscience, or a related field preferred

Skills

• High integrity and strong professional judgment