Head of Clinical Development

About the role

A growing AI-driven company with clinical-stage programmes and the capital to match its ambition needs someone to own those assets end to end. As Head of Clinical Development, you will report directly to the CEO and serve as the single accountable leader for your programme(s).

Responsibilities

• Own the full development strategy for one or more oncology assets, from IND-enabling activities through to registrational planning, and serve as the single voice into portfolio governance and investment decisions.
• Design precision, biomarker-driven protocols by translating foundation model predictions and real-world evidence into trial designs that identify the right patient populations sooner.
• Define regulatory strategy and act as senior sponsor in FDA and EMA interactions, owning the clinical and scientific content of briefing books, IND amendments, and key submissions.
• Lead medical oversight across active studies, using platform dashboards to track enrolment, safety signals, and biomarker data in real time from site activation through to closeout.
• Direct your cross-functional team of clinical and scientific staff and orchestrate a fleet of AI agents to execute document-heavy tasks that would traditionally consume a development leader's calendar.
• Provide matrix leadership across biostatistics, medical monitoring, data management, and clinical operations, aligning functional experts around the priorities of the asset.
• Own and develop investigator and KOL relationships for your programme, and maintain a sharp view of the competitive and scientific landscape to inform development decisions.
• Make the high-judgement scientific and commercial calls, including go or no-go decisions, that determine where the programme goes at each milestone.

Requirements

MD or MD/PhD with substantial oncology drug development experience, ideally including breast cancer or NSCLC programmes. Ten or more years in drug development, including senior leadership as a VP or SVP of Clinical Development at a pharmaceutical company, or as CMO at a biotech. Demonstrated end-to-end ownership of a clinical asset, covering regulatory strategy, protocol design, health authority interactions, and pipeline-level go or no-go decisions. Genuine openness to working in an AI-first, non-hierarchical environment.

Qualifications

N/A

Skills

N/A

Benefits

N/A

Pay

$450K–525K a year

Schedule

Hybrid- 3 days a week on site in New York