Genotyping Chemistry Scientist

About the role

The Genotyping Chemistry Scientist will play a crucial role in designing, developing, and optimizing high-multiplex PCR assays and targeted Genotyping-by-Sequencing (tGBS) kits for high-throughput plant breeding applications. This individual will manage external synthesis, lead projects through the Stage Gate process, and stay at the forefront of emerging trends in genotyping chemistry.

Responsibilities

• Design & Optimize: Architect high-multiplex PCR assays and tGBS workflows, optimizing primer design, pool chemistry, and amplification parameters for high-throughput genotyping.
• Manage External Synthesis: Serve as the technical liaison with external oligonucleotide synthesis vendors. Apply knowledge of synthesis chemistry to define specifications, evaluate quality control data, and troubleshoot synthesis-related assay failures.
• Lead Projects: Drive assay and kit development projects through the Stage Gate process, ensuring rigorous validation, scale-up feasibility, and seamless integration into production.
• Collaborate Globally: Partner closely with molecular biologists, bioinformaticians, and automation engineers to integrate newly designed assays into automated laboratory workflows.
• Stay Cutting-Edge: Maintain Syngenta’s competitive edge by scouting and implementing emerging trends in multiplex PCR chemistry, enzymes, NGS-based genotyping, and assay design software.

Qualifications

• Ph.D. in Molecular Biology, Genetics, Biochemistry, Bioengineering, or a related field. A Master’s degree with extensive relevant experience may be considered.
• 6+ years of experience in genotyping applications, assay development, or molecular diagnostics.
• Proven track record in designing and validating high-multiplex PCR assays (e.g., design of panels with dozens to hundreds of targets).
• Strong familiarity with oligonucleotide chemistry, modification options, and synthesis/purification processes (to facilitate effective vendor management).
• Expertise in primer/probe design software and bioinformatics pipelines for multiplex PCR and tGBS.
• Hands-on experience with NGS-based genotyping workflows (tGBS, amplicon sequencing) and endpoint/real-time PCR.
• Experience with assay validation, buffer optimization, and enzyme selection for robust performance.
• Strong data analysis skills, including the ability to interpret DNA sequence and genotyping data to iterate assay designs.

Additional Information

Syngenta offers a full benefit package including Medical, Dental & Vision insurance, a 401(k) plan with company match, profit sharing, and retirement savings contribution. Other benefits include paid vacation, holidays, maternity and paternity leave, education assistance, wellness programs, corporate discounts, and more. The salary range for this position is $104,800 - $157,200.

Learn more about our team and our mission.

Equal Opportunity Employer. Syngenta is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, disability, veteran status, or any other characteristic protected by law.