FDA Postdoctoral Fellowship in In Vitro Cardiotoxicology Models
Oak Ridge Institute for Science and Education · Jefferson, AR · 1 wk ago
On-siteResearchInternship
Research Project
The National Center for Toxicological Research (NCTR) aims to study the effects of 6PPD and 6PPDQ on the cardiovascular system using isogenic iPSC-derived immuno-cardiac NAMs. This research seeks to understand the long-term, low-dose effects of these compounds in humans, particularly in individuals with cardiovascular disease (CVD).
Mentor
Li Pang
Learning Objectives
- Learn to optimize the co-culture system using flow cytometry, immunofluorescence, and microelectrode array (MEA) to characterize the cells.
- Utilize real-time impedance and live-cell imaging to assess the effects of exposure on cells.
- Gain proficiency in measuring functional endpoints including beat rate, contractility, rhythm regularity, field potential duration, and arrhythmia susceptibility.
- Gain experience in analyzing gene expression profiles and identifying affected pathways.
- Develop collaboration skills to formulate hypotheses, record experimental data, prepare reports, and interpret experimental results.
- Present research findings at local and national conferences and in journal publications.
Qualifications
- Currently pursuing or having received a doctoral degree in relevant fields such as Chemistry and Materials Sciences, Communications and Graphics Design, Computer, Information, and Data Sciences, Earth and Geosciences, Engineering, Environmental and Marine Sciences, Life Health and Medical Sciences, Mathematics and Statistics, Physics, Science & Engineering-related, or Social and Behavioral Sciences.
- A U.S. citizen or having lived in the United States for at least 36 out of the past 60 months.
- Read and sign the FDA Education and Training Agreement within 30 days of the start date.
- Read and agree to the FDA Ethics Requirements.
Contact
To submit your application, scroll to the bottom of this opportunity and click APPLY. All documents must be in English or include an official English translation. If you have questions, send an email to ORISE.FDA.NCTR@orau.org. Please include the reference code for this opportunity in your email.