Experienced Clinical Project Manager - Inflammation (Sponsor Dedicated/ Remote- US only)

Syneos Health® is a leading fully integrated biopharmaceutical solutions organization built to accelerate customer success. We translate unique clinical, medical affairs and commercial insights into outcomes to address modern market realities. Our Clinical Development model brings the customer and the patient to the center of everything that we do.

About the Role

This is a highly visible opportunity supporting a complex Phase 2b inflammation program within a fast-paced sponsor-dedicated environment where strong operational leadership, accountability, and execution matter. The ideal candidate is comfortable operating both strategically and tactically — someone who can lead cross-functional teams while also rolling up their sleeves and working in the details to keep a study moving forward.

• High-impact role supporting a complex Phase 2b inflammation study
• Opportunity to lead regional execution efforts within a large global clinical program
• Strong visibility across Clinical Operations, leadership, and external partners
• Fast-moving environment where decisions and execution happen quickly
• Significant ownership and autonomy with the expectation to independently drive study progress
• Collaborative sponsor-dedicated culture with supportive leadership and strong team partnership
• Opportunity to work alongside highly experienced clinical operations professionals in a hands-on environment

Responsibilities

End-to-End Clinical Trial Execution

• Drive operational execution of a complex Phase 2b inflammation study from study start-up through database lock and closeout
• Independently manage day-to-day study operations with minimal oversight
• Own timelines, deliverables, risks, and issue resolution across multiple workstreams
• Maintain deep operational awareness across all aspects of the trial — this is a role for someone comfortable working “in the weeds”
• Ensure study milestones stay on track in a fast-paced environment with shifting priorities and competing demands
• Partner cross-functionally to proactively identify risks, remove roadblocks, and implement operational solutions quickly

Vendor & CRO Oversight

• Lead vendor management activities and maintain strong oversight of external partners and CROs
• Contribute to RFP development, vendor selection, and ongoing vendor performance management
• Hold vendors accountable to timelines, deliverables, quality expectations, and issue resolution
• Actively manage operational follow-through rather than relying solely on escalation pathways

Cross-Functional Leadership

• Lead cross-functional meetings with clear agendas, action-oriented discussions, and strong follow-up
• Drive accountability across internal teams and external partners
• Build strong collaborative relationships while effectively navigating challenging conversations and competing priorities
• Mentor or support junior team members as needed
• Operate confidently within a matrixed global environment with multiple stakeholders

Study Operations & Documentation

• Draft, review, and coordinate key study documents including protocols, informed consents, monitoring plans, investigator brochures, and clinical study reports
• Support study budget tracking, forecasting, and operational planning activities
• Review data listings and support interim/final reporting activities
• Train CROs, investigators, study coordinators, and vendors on protocol and study requirements
• Contribute to SOP development, process improvement initiatives, and operational best practices

Requirements

• 3+ years of clinical project management experience within clinical research
• Experience running clinical trials from start-up through closeout, with a strong understanding of the full clinical trial lifecycle
• Experience supporting complex Phase 2b studies within the inflammation therapeutic area
• Strong CRO/vendor management and oversight experience
• Proven ability to independently drive study execution in fast-paced clinical environments
• Experience managing cross-functional clinical trial activities within matrixed organizations
• Comfortable balancing strategic oversight with hands-on operational execution

Skills

• Highly organized with exceptional follow-through and attention to operational detail
• Comfortable working in the weeds while still maintaining a high-level program perspective
• Ability to prioritize effectively and pivot quickly in fast-moving environments
• Strong meeting leadership, communication, and stakeholder management skills
• Confident driving accountability across teams and vendors
• Solutions-oriented mindset with strong initiative and urgency
• High emotional intelligence and ability to navigate high-stakes conversations professionally
• Collaborative, transparent, and team-oriented approach
• Thorough knowledge of FDA and EMA regulations, ICH Guidelines, and GCP requirements
• Strong working knowledge of Microsoft Word, Excel, and PowerPoint
• Ability to interpret and explain protocol requirements, operational processes, and study expectations to teams and stakeholders

Team Culture

This team values collaboration, accountability, and execution. The environment is fast-paced, highly interactive, and best suited for individuals who enjoy being actively engaged in study operations rather than operating at a distance. Leadership is approachable, mentorship-focused, and supportive, while still maintaining high expectations around ownership and delivery. The team works hard, communicates openly, and genuinely supports one another to keep studies moving forward successfully.

Benefits

• Company car or car allowance
• Health benefits to include Medical, Dental, and Vision
• Company match 401k
• Eligibility to participate in Employee Stock Purchase Plan
• Eligibility to earn commissions/bonus based on company and individual performance
• Flexible paid time off (PTO) and sick time

Pay

The base salary range represents the anticipated low and high of the Syneos Health range for this position. Actual salary will vary based on various factors such as the candidate’s qualifications, skills, competencies, and proficiency for the role.