Executive Director, Clinical Scientist

About the role

The Executive Director, Clinical Scientist at Madrigal is responsible for the strategic and scientific leadership across clinical programs, driving study design, execution, and cross-functional alignment to advance assets through development and toward regulatory milestones.

Responsibilities

• Provide strategic and scientific leadership across clinical programs, driving study design, execution, and cross-functional alignment to advance assets through development and toward regulatory milestones.
• Contribute to the design and development of clinical trial protocols, including scientific rationale, study objectives, endpoints, and eligibility criteria.
• Author or review key clinical documents such as investigator brochures, informed consent forms, clinical study reports (CSRs), and regulatory submissions.
• Provide scientific input during trial execution, including protocol amendments, site engagement, data reviews, and ongoing study support.
• Collaborate with clinical operations, data management, biostatistics, and medical writing to ensure high-quality trial conduct and data integrity.
• Conduct data reviews and support data interpretation in collaboration with biostatistics and the medical team.
• Support the preparation of documents for regulatory submissions, health authority meetings, and internal governance presentations.
• Stay current on therapeutic area trends, competitive landscape, and regulatory guidance related to MASH/NASH and associated comorbidities.
• Participate in cross-functional meetings and contribute to development strategies and timelines.

Requirements

• Advanced degree (PhD, MD, PharmD, or equivalent) in a life sciences field required; Master’s with relevant experience may be considered.
• 12+ years of experience in clinical development or clinical research within the pharmaceutical or biotechnology industry.
• 18+ years relevant experience.
• Prior experience in liver disease, metabolic disorders, or MASH/NASH strongly preferred.
• Solid knowledge of ICH/GCP and global clinical trial regulations.
• Demonstrated ability to synthesize complex scientific data and present it clearly and effectively.
• Excellent verbal and written communication skills.
• Collaborative mindset with strong organizational and project management abilities.

Preferred Attributes

• Experience working in a fast-paced biotech environment with small, agile teams.
• Familiarity with liver disease endpoints such as histology, imaging, or non-invasive biomarkers.
• Experience supporting regulatory interactions or submissions is a plus.

Pay

A good faith estimate of the current pay scale for this position, applicable to all candidates, is $288,000 - $352,000 per year. We comply with all applicable minimum wage laws.

Benefits

All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws.