E11 Bio - Senior Research Associate - in vivo

Responsibilities

• Take ownership of all animal perfusions, including preparation of perfusates, execution of procedures, troubleshooting tissue-quality issues, and continuous improvement of fixation protocols.
• Execute and support in vivo surgical workflows, including stereotaxic and retro-orbital viral injections, post-operative monitoring, and animal welfare documentation.
• Apply scientific training to monitor, control, and systematically optimize key in vivo and perfusion parameters for tissue labeling + preservation.
• Collaborate closely with experimental scientists to design, execute, and troubleshoot in vivo labeling experiments, contributing technical judgment and experimental insight.
• Perform routine animal health checks and husbandry tasks as needed, with attention to health or behavioral changes that may impact experimental outcomes.
• Maintain accurate experimental records, reproducible protocols, and operational readiness of perfusion and surgical equipment.
• Contribute to a positive, collaborative lab culture and run small, focused experimental projects.

Requirements

• Hands-on experience performing animal perfusions using PFA or related fixatives for neuroscience or brain tissue applications, with the ability to produce consistent, high-quality tissue.
• Demonstrated ability to quickly learn, independently own, and optimize complex biological workflows, including diagnosing and resolving tissue-quality or protocol failures.
• Experience with rodent handling, restraint, and basic health assessment in a research setting.
• Strong record of reliability, precision, and careful experimental documentation.
• Clear communication skills and a proven ability to collaborate effectively within interdisciplinary research teams.

Preferred Qualifications

• Mechanical or technical aptitude for maintaining, adjusting, or troubleshooting perfusion rigs, surgical setups, and related laboratory hardware.
• Experience with in vivo surgical techniques such as stereotaxic or retro-orbital viral injections (or strong interest and aptitude to train into these methods).
• Familiarity with downstream histology, imaging, or molecular tissue workflows.
• Interest in neuroscience and connectomics, with motivation to contribute to technically demanding, high-impact research.