E11 Bio - Scientist/Senior Scientist, Molecular Engineering & Sample Optimization
CHEManager International · Alameda, CA · 3 days ago
Analyst$100k–$191k/yrFull-time
Responsibilities
- Develop and deploy an assay to systematically evaluate and improve the fixation quality and preservation of brain tissue
- Establish and integrate quantitative metrics of molecular readout, e.g. protein retention, antigenicity, and labeling quality across tissue preparation conditions
- Work closely with in vivo research technicians to design experiments, evaluate results, and optimize Standard Operating Procedures (SOPs)
- Drive the development of data-analysis pipelines to routinely generate key performance indicators of sample tissue quality
- Generate an in-house pipeline for binder design/discovery, validation, and optimization of epitope-binder pairs in hydrogels to improve the readout of epitope barcode bits and relevant native synaptic proteins
- Develop novel highly multiplexed protein readout strategies for protein barcodes and molecular annotation of synapses and cell types
Requirements
- Mission-aligned experimental scientist with a strong background in neuroscience and molecular biology
- Experience in developing and deploying assays for tissue preparation and molecular readout
- Ability to work effectively in a multidisciplinary team environment
- Strong quantitative skills and proficiency in data analysis
- Experience with in vivo research techniques and standard operating procedures
- Knowledge of hydrogel technology and its application in protein readout
- Experience with multiplexed protein readout strategies
Qualifications
- PhD in Neuroscience, Molecular Biology, or related field
- At least 3 years of postdoctoral experience or equivalent industry experience
- Experience with high-throughput sequencing and bioinformatics tools
- Experience with microscopy and image analysis software
- Excellent communication and collaboration skills
Skills
- Strong analytical and problem-solving skills
- Experience with machine learning and AI tools
- Proficiency in programming languages such as Python, R, or MATLAB
- Experience with database management systems
- Experience with cloud computing platforms
Benefits
- Competitive salary range: $100,000 - $191,000 per year
- Up to 20% team performance-based bonus
- 401(k) match up to 6% of base salary