Drug Discovery Scientist

About The Work Unit

The Drug Discovery Scientist is part of the Basic Sciences Pod 3 in the School of Medicine at Vanderbilt University and is a key individual contributor responsible for designing, developing and conducting experiments. This position requires excellent communication skills; including presenting verbal and written reports to the project team. The highly motivated scientist will be an integral part of the drug discovery team and be willing to assist in other responsibilities. Reporting to the Principal Investigator or project leader, the Drug Discovery works with faculty, staff, and other members of the Team.

Key Functions And Expected Performance

• Oversee/facilitate the design, execution, analysis, and reporting of a wide range of small molecule discovery-stage in vivo DMPK assays and studies (non-GLP).
• Maintain up to date, accurate, and standardized records of experiments/assays.
• Shared supervision and management of research assistants, laboratory operations/instrumentation, and DMPK group resources and deliverables.
• Write and submit IACUC protocols and manage existing protocols.
• Interact with the IACUC and Animal Facility personnel to resolve potential issues and day-to-day operation.
• Handle small animals and prepare them for DMPK experiments.
• Administer small molecule compounds PO, IP, IV or SC.
• Draw blood at specific time points and prepare plasma for shipping to DMPK lab.
• Collect tissues as requested by DMPK lab.
• Follow University safety protocols (may include use of combustibles, biohazardous materials and fluids/tissues, and/or carcinogens).
• Representation of DMPK on multiple drug discovery program teams, including participation in recurring meetings/TCs (infrequent travel requirements).
• Obtain DMPK data via a network of domestic and international contract research organizations (CROs), including coordination of contracts and shipping logistics.
• Train new personnel.

Education And Experience

• Ph.D. degree in pharmacology, biochemistry, or a related field with a minimum of 5 years of relevant experience in a similar position within a pharmaceutical company, biotechnology company, or academic drug discovery organization is required.
• Strong organizational, inter-personal/communication, and analytical skills with the ability to manage several responsibilities simultaneously in a fast-paced and dynamic work environment.
• In-depth knowledge and understanding of fundamental principles of pharmacology, pharmacokinetics, and biochemistry/enzymology; familiarity with PK related FDA/EMA regulatory guidance.
• Experience with use of Prism (or related), and other standard laboratory/office computer programs (e.g., MS Office) for analysis and reporting of DMPK data.
• Ability to work independently (i.e., self-motivated) with low supervision, flexible hours, and on repetitive tasks with a shared respect for the long term goals and mission of the organization.

General Characteristics Of a Successful Vanderbilt University Staff Member

• Acceptance of Feedback – Takes constructive criticism with grace, and make improvements without taking it personally or holding grudges.
• When wrong, owns it – freely admits mistakes.
• Adaptability – Reads cues and adapt accordingly. Adjusts style and approach to accommodate the styles and needs of others. Can anticipate and effectively de-escalate potential conflicts.
• Analytical & Detail-Oriented – Accurately assesses information and applies applicable law, policy and procedure. Considers the long term implications of actions today and advises employees appropriately. Even small mistakes can create big issues; attention to detail work indicates care about the outcomes.
• Assumes Positive Intent – Assume that others are working and taking action with good intentions. They may not have all the information yet and asking thoughtful questions and providing information is critical to mutual understanding and moving forward with success.
• Autonomous – Self-managing; self-motivated. Manages time, activities and outcomes well so that progress stays on track. Cleans up after themselves.