Downstream Process Development Co-Op

About the role

At Keros, our mission is to deliver significant clinical benefit to a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (TGF-ß) family of proteins. With a focus on developing differentiated product candidates that are designed to alter TGF-β signaling, we aim to target the pathways critical for the growth, repair and maintenance of blood cells and a number of tissues, including bone, skeletal muscle, adipose and heart tissue. We believe our product candidates have the potential to unlock the full therapeutic benefits of modulating the TGF-β superfamily and provide disease-modifying benefit to patients.

Job Summary: This role is responsible for experiment execution in downstream biologics process development. This will include equipment setup, maintenance, processing, and data acquisition in a laboratory setting. Technical report authoring and lab notebook recordkeeping are also critical to this role. A successful candidate will exhibit strong interpersonal skills, technical competence, and a willingness to learn.

Responsibilities

• Scale-down and range finding study execution.
• Purification by FPLC of Pilot scale batches.
• Implementation of multiple liquid chromatography types (i.e Affinity, Ion Exchange, HIC)
• Buffer formulation, resin selection and capacity study execution.
• Filter loading and fouling study execution.
• Intermediate stability analysis.
• Formulation and stability study support.
• Protein characterization by A280, SEC, SDS-PAGE and cIEF.
• Statistical data analysis.
• Equipment setup, functional verification and maintenance.

Qualifications

• Currently enrolled in a biology, chemistry, chemical engineering, bioengineering, molecular biology or related program.
• Familiar with protein biochemistry
• Familiar with general biology lab techniques
• Familiar with statistical analysis and experimental design
• Technical and scientific writing and presentation skills

Pay

This pay range represents the base hourly rate or base annual full-time salary for all positions in the job grade within which this position falls. The actual base salary offer will depend on a variety of factors including experience, education, and other relevant factors. Potential base pay range $28—$32 USD