Distinguished Scientist, Group Head Biochemistry
BioSpace · Cambridge, MA · 2 wk ago
On-siteAnalystFull-time
Key Responsibilities
- Provide strategic direction and scientific oversight for biochemistry activities supporting multiple drug discovery programs across diverse therapeutic areas
- Serve as the primary biochemistry expert and thought leader, guiding project teams on assay design, target characterization, and mechanism of action studies
- Drive innovation in biochemical assay technologies and methodologies to enhance drug discovery capabilities
- Establish and maintain scientific standards and best practices for biochemistry within In Vitro Biology
- Represent biochemistry expertise in cross-functional project teams and governance committees
- Use AI/ML and robotics to accelerate drug discovery cycle times.
Team Leadership & Development
- Lead, mentor, and develop a team of biochemists, fostering a culture of scientific excellence and collaboration
- Recruit, retain, and develop top scientific talent to build a world-class biochemistry organization
- Create an inclusive environment that encourages innovation, continuous learning, and professional growth
- Promote Sanofi's values of Aim Higher, Act for Patients, Be Bold, and Lead Together within the team
Drug Discovery Execution
- Oversee the design, development, and execution of biochemical assays for target validation, hit identification, and lead optimization
- Ensure timely delivery of high-quality biochemistry data to support project milestones and decision-making
- Collaborate with medicinal chemistry, structural biology, pharmacology, and other disciplines to advance compounds through discovery stages
- Troubleshoot complex biochemical challenges and provide innovative solutions to overcome technical obstacles
- Evaluate and implement emerging technologies and platforms to enhance biochemistry capabilities
Collaboration & Communication
- Partner effectively with internal stakeholders across Research, Development, and Global functions
- Build and maintain external collaborations with academic institutions, biotechnology companies, and contract research organizations
- Present scientific findings and strategic recommendations to senior leadership
- Contribute to scientific publications, patents, and presentations at external conferences
- Participate in scientific advisory boards and industry forums as a Sanofi representative
Required Qualifications
- Education & Experience: Ph.D. in Biochemistry, Chemical Biology, Molecular Biology, or related scientific discipline and 8+ years of progressive experience in pharmaceutical or biotechnology drug discovery industry. At least 5+ years of people management experience, including leading and developing scientific teams
- Technical Expertise: Deep expertise in biochemical assay development and characterization across multiple target classes (enzymes, protein-protein interactions, epigenetic targets, etc.). Strong understanding of enzyme kinetics, binding thermodynamics, and structure-activity relationships. Hands-on experience with diverse biochemical techniques including fluorescence, luminescence, mass spectrometry, surface plasmon resonance, and other biophysical methods. Expertise in the field of protein degradation or molecular glues (degraders-non degraders). Understanding of drug discovery processes from target identification through clinical candidate nomination
- Leadership & Interpersonal Skills: Demonstrated ability to lead, motivate, and develop high-performing scientific teams. Excellent strategic thinking and problem-solving capabilities. Strong communication skills with ability to influence and align diverse stakeholders. Proven ability to manage multiple priorities and deliver results in a fast-paced environment. Collaborative mindset with experience working in matrix organizations
Preferred Qualifications
- Experience with novel therapeutic modalities such as targeted protein degradation, molecular glues, covalent inhibitors, or allosteric modulators
- Expertise in specific therapeutic areas of strategic importance to Sanofi (immunology, oncology, rare diseases, neuroscience)
- Track record of scientific publications in high-impact peer-reviewed journals
- Experience with regulatory submissions and interactions with health authorities
- Familiarity with AI/ML applications in drug discovery and computational biochemistry
- Previous experience in a Level 4+ leadership role within a pharmaceutical organization
- Established network within the scientific community and industry