Discovery ADME Project Leader

About the role

We are seeking an experienced, accomplished drug hunter as a Discovery ADME Project Leader. The ideal candidate will provide deep mechanistic understanding of drug disposition, PK, and translational science, plus the ability to integrate biology, chemistry, and modeling.

Responsibilities

• Develop and execute integrated preclinical ADME strategies aligned with discovery stage, target product profile (TPP), design hypotheses being tested, and regulatory expectations.
• Integrate ADME and pharmacology to enable translational simulations and modeling to support dose selection, design of PK/PD, efficacy, and safety studies.
• Define stage-, modality-, and issue-appropriate profiling, decision funnels (in silico, in vitro, in vivo to translational modeling).
• Guide compound design and optimization through data-driven design principles (clearance, permeability, solubility, DDI risk, transporter liabilities).
• Serve as the ADME strategy and science single-point-of-accountability on cross-functional program teams, translating ADME findings into actionable design and test hypotheses.
• Collaborate closely with Medicinal Chemistry, DMPK, Toxicology, Pharmacology, and other Discovery Functions to drive high quality candidate selections.
• Contribute to go/no-go decisions using quantitative PK/PD, IVIVE, and mechanistic interpretation.
• Represent ADME in portfolio governance discussions and leadership reviews.
• Implement best practices, assay innovation, and automation where appropriate.
• Drive continuous improvement in data reporting, knowledge management, and decision frameworks.
• Seek, leverage and deploy AI and agentic tools where possible to pipeline data, interpret data and share/accelerate results.
• Maintain inspection-ready documentation and alignment with regulatory expectations.
• Mentor, teach and grow junior scientists and contribute to functional capability building.

Requirements

• PhD (or equivalent) in Pharmaceutical Sciences, Pharmacokinetics, Pharmacometrics, Systems Pharmacology, Preclinical or Clinical Pharmacology, Drug Metabolism, Toxicology, Chemical Biology, or related field.
• Minimally 3+ years of post-graduation industry experience in a drug discovery environment, driving discovery teams.
• Exceptional written and verbal communication skills; ability to successfully navigate ambiguity and/or global cross-functional collaborations.
• Demonstrated ability to translate complex technical concepts into strategic value for senior leadership and cross-functional partners.