Director, Translational Pharmacokinetics - DMPK
About the role
For our client, we are seeking a Director, Translational Pharmacokinetics - DMPK to join the team of a leader in the Pharmaceuticals & Biotech space. This leader is seeking an experienced scientific professional to shape translational pharmacokinetic strategy and inform critical development decisions across the drug pipeline. In this role, you will build and apply PK and PKPD models that help translate preclinical and clinical data into actionable dosing, safety, and regulatory insights. You will partner closely with cross-functional development teams to support first-in-human planning, model validation, and submissions that advance programs with confidence.
Responsibilities
- Design and implement PBPK models to simulate drug behavior
- Create and evolve PKPD models using clinical and nonclinical data
- Support first-in-human dose projections for drug candidates
- Integrate diverse experimental data to improve model accuracy
- Provide simulations for regulatory submissions and decision-making
- Collaborate with cross-functional teams to validate models
- Conduct simulations to predict drug-drug interactions and optimize dosing strategies
Qualifications
- PhD, PharmD, or equivalent advanced scientific degree
- 12+ years of industry experience in PBPK and PKPD modeling
- Experience with IND-enabling programs and regulatory submissions
- Solid understanding of ADME principles
- Proficiency in pharmacokinetic modeling software such as Simcyp and GastroPlus
- Ability to critically evaluate experimental data
- Experience in a collaborative biotechnology environment
Benefits
- Eligibility for a company-sponsored 401(k) and pension
- Vacation benefits
- Medical, dental, vision, and prescription drug benefits
- Flexible spending accounts for healthcare and dependent care
- Life insurance and death benefits
- Well-being benefits including employee assistance programs and fitness benefits
- Participation in company bonus programs based on performance
Pay
$177,000 – $283,800 annually
Schedule
Remote — US-based candidates only; no visa sponsorship available.