Director, Translational Oncology

About the role

Reporting to the VP, Translational Oncology, the Director, Translational Oncology will be responsible for developing and executing translational and clinical biomarker strategies across ALX Oncology's oncology portfolio of early and late stage assets. This individual will work closely with Clinical Development, Clinical Operations, Biometrics, Regulatory, Research, and external partners to translate scientific insights into clinical development strategies, including patient selection, pharmacodynamic and resistance biomarkers, molecular response endpoints, indication selection, and combination strategies. Preference will be given to candidates who can regularly work onsite Mondays and Tuesdays as part of the company's hybrid work model.

Responsibilities

• Contribute to a culture that reflects ALX's values by acting with integrity, accountability, transparency, and respect.
• Build strong, collaborative relationships through active engagement with colleagues, including regular onsite participation consistent with the company's hybrid work model.
• Develop and execute translational and clinical biomarker strategies to support oncology development programs, including predictive, pharmacodynamic, and resistance biomarkers, molecular response endpoints, patient and indication selection, and combination strategies.
• Lead the biomarker components of clinical trials, including protocol development and implementation of biomarker, pharmacodynamic, and patient stratification strategies.
• Oversee the selection and management of CROs and laboratory partners, including evaluation of assay and technology platforms, development of scopes of work, data analysis capabilities, and execution of external services.
• Partner closely with Clinical Development and Clinical Operations to integrate scientific and clinical strategy with clinical sample collection, processing, storage, analysis, and data transfer.
• Analyze and integrate biomarker data with clinical endpoints to generate insights that inform clinical development strategy and decision-making.
• Contribute translational and biomarker content to regulatory documents, including Investigator's Brochures, IND submissions, and responses to health authority questions.
• Build productive relationships and collaborations with scientific leaders,