Director/Sr. Director/Exec. Director Computational Biophysics, Advanced Molecular Design (AMD)

About the role

Lilly’s Advanced Molecular Design (AMD) team is responsible for small molecule lead optimization with rapid progress toward new clinical candidates for patients in need. The AMD team is seeking an exceptional computational biophysicist to tackle the problems our discovery teams have yet to solve.

Responsibilities

• Develop and deploy advanced physics-based algorithms to characterize biophysical processes and their application across a range of therapeutic areas
• Play a key role in prioritizing computational methods and workflows to efficiently and effectively enable drug discovery efforts leading to highly focused work and rapid progress
• Maintain critical timelines and set team expectations for the efficient delivery of computational technologies with strong impact on therapeutic programs
• Work closely with other AMD and therapeutic area leaders to move our portfolio of molecules from leads to quality drug candidates that have a strong potential to become breakthrough drugs
• Contribute to the ongoing evaluation of external technologies

Requirements

• Ph.D. in physics, chemistry, mathematics, computer science or related discipline with 10 or more years of research experience

Qualifications

• A deep scientific background in theoretical and computational biophysics
• Proven track record of leadership and success applying computational biophysics toward a deeper understanding of structure-function relationships in human health
• Proactive and effective collaboration with computational chemists, medicinal chemists, structural biologists, and other disciplines to achieve project goals and timelines
• A strong desire to establish a deeper understanding of all aspects of drug discovery, including conformational ensembles of biological systems, small molecule-protein interactions, physicochemical properties, and ADMET
• A proactive and highly engaged approach to solving challenging problems in drug discovery
• A desire to stay continually up to date with the latest industry developments and novel techniques employed in discovery, including statistical mechanics, free-energy and enhanced sampling methods, AI, and machine learning models
• Excellent communication of goals and priorities to discovery teams
• Agility and adaptability to change research priorities as necessary for success
• A commitment to mentoring earlier career scientists
• A strong core desire to help patients in need

Skills

• Ability to think at the level of first principles
• Ability to build whatever tools are necessary
• Measure success not by workflows delivered but by scientific understanding created

Benefits

The physical demands of this job are consistent with an office environment. The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Travel may be required.

Pay

The anticipated wage for this position is $193,500 - $338,800

Schedule

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance).

Additional Information

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities).

Learn more about all of our groups. Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $193,500 - $338,800 Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).