Director, Small Molecule Discovery Biology (Inflammation & Autoimmunity)

Key Responsibilities

• Taking biology department responsibility in discovery-stage small molecule projects including conceptualizing project strategy, recognizing knowledge gaps, formulating screening paradigms, overseeing SAR generation, coordinating among project stakeholders, and identifying potential new targets
• Overseeing development of both biochemical and cellular read-outs to support small molecule drug discovery efforts
• Support characterization of small molecule clinical candidates by employing autoimmune disease models and developing clinically relevant PD assays
• Providing both direct and indirect supervision of laboratory-based biology staff
• Managing external biology studies performed at CROs.
• Collaborating effectively with cross-functional teams including medicinal chemistry, DMPK, and preclinical development.
• Ensuring effective communication and coordination with departmental and company-wide leaders on project strategy and progress toward goals

Ideal Candidate

• PhD with 8+ years biopharma work experience in immunology-related small molecule drug discovery
• Prior experience with function-level oversight of project biology and/or biochemistry efforts, or overall project team leadership
• Knowledge of and hands on experience with emerging areas of small molecule drug discovery, such as protein-protein interaction inhibitors, degraders and molecular glues, and transcription factors
• Expertise spanning from early-stage target discovery and validation through early clinical development
• Experience with compound screening, characterizing mechanism of action, transcriptomics, and proteomics
• Awareness of autoimmune disease biology including in vitro and in vivo immunology models, immortalized cell lines, isolation and characterization of primary immune cells, RNA-Seq, and cytokine detection methodologies
• Experience managing CRO collaborations, with an existing familiarity of a wide variety of biology CROs
• Excellent interpersonal skills with the ability to work both independently and cross-functionally to advance drug discovery programs; experience working with academic collaborators is a plus
• Experience in direct and indirect supervision of junior staff members
• Familiarity and enthusiasm for working in a small company environment
• Track record of scientific achievement and innovation

Pay

The salary range for this position is $200,000 USD to $240,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company's compensation practices. Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program. Other Benefits Include Health insurance premiums paid at 90% for employee, 80% for dependents Free access to Genentech Bus & Ferry Share program $100 monthly cell phone stipend Unlimted PTO for Exempt employees Free onsite gym and a kitchen stocked with yummy snacks and drinks!