Director/ Senior Director / Executive Director – Translational PKPD Project Leader

About the role

Eli Lilly and Company is seeking a scientific director with experience in mechanistic PK, PK/PD, and/or PBPK modeling to support genetic medicines programs. The ideal candidate will have experience with ASOs, siRNA, LNP-mediated delivery, gene therapy (AAV and non-viral vectors), and antibody-siRNA conjugates (ARC).

Responsibilities

• Serve as the Discovery PKPD project leader for genetic medicines programs.
• Develop and implement modeling strategies that enhance decision-making for genetic medicines inform translational research strategies.
• Design, analyze, and interpret quantitative pharmacology and PK/PD studies.
• Collaborate effectively with scientists within and outside the functional area to integrate PK/PD into team strategy and contribute to project team discussions, guiding key go/no-go decisions with quantitative approaches.
• Communicate quantitative findings both internally and externally through scientific publications, conference presentations, and cross-functional forums.
• Mentor junior scientists and contribute to the growth of PKPD modeling capabilities within the genetic medicines space and neuroscience space.

Qualifications

• PhD in Pharmacokinetics/Pharmacodynamics, Pharmacology, Pharmaceutical Sciences, Biomedical engineering, or a related subject area with 5 or more years of relevant industry or CRO experience in translational and/or mechanistic PKPD modeling.
• Experience with empirical or mechanistic PK/PD modeling to support drug discovery and/or development.
• Experience with DMPK and translational PK/PD modeling to support interspecies scaling, human dose projections, and first-in-human study design.
• Experience with relevant modeling and simulation software such as NONMEM, mrgsolve, MATLAB, Monolix, SimCYP, PKSim, or equivalent platforms.
• Experience working effectively in a cross-functional, matrixed collaborative environment.

Additional Skills/Preferences

• Visible commitment to mentorship, sponsorship, and career growth.
• Therapeutic area expertise within neuroscience.
• Experience with PKPD or PBPK modeling applied to oligonucleotide therapeutics (ASO, siRNA), LNP delivery platforms, gene therapy (AAV or non-viral), and/or antibody-siRNA conjugates (ARCs).
• Understanding of the outstanding disposition, intracellular delivery, tissue distribution, and Pharmacodynamics and durability of nucleic acid-based therapeutics.
• Excellent self-management, organizational skills, and ability to manage multiple programs simultaneously.
• Publication record in peer-reviewed journals in quantitative pharmacology, genetic medicines, or related fields.