Director, Protein Sciences

About the role

Johnson & Johnson Innovative Medicine R&D is recruiting for a Director, Protein Sciences. This position is a hybrid role and can be located in Spring House, PA or Cambridge, MA.

Responsibilities

• Evaluate therapeutic targets, including structural, sequence, and domain architecture analysis
• Integrate internal and external data (literature, databases, structural repositories)
• Define antigen and engineered-cell design strategies to support antibody discovery
• Construct design and domain selection
• Epitope exposure and conformational state optimization
• Strategies for difficult targets (e.g., multi-pass membrane proteins) including Nanodisc technology and nucleic acid immunogen design
• Apply computational and structural biology approaches to protein design
• Homology modeling, structural analysis, and rational mutagenesis
• Engineer proteins to improve stability and expression
• Functional relevance for discovery assays and immunization

Requirements

• A minimum of a Ph.D. in Biochemistry, Structural Biology, Protein Engineering, or a related discipline
• A minimum of 10 years of experience in biologics discovery or protein sciences
• Demonstrated leadership experience within the pharmaceutical or biotech industry
• Strong knowledge in antigen design and generation for antibody discovery; structural biology and protein sequence analysis; biologics discovery workflows from target to lead identification
• Experience or domain knowledge in Oncology, Immunology, and/or Neuroscience
• Excellent verbal and written communication skills
• Strategic with a strong scientific mindset
• The ability to operate effectively within a highly coordinated, fast-paced matrix environment

Qualifications

• Ph.D. in Biochemistry, Structural Biology, Protein Engineering, or a related discipline
• Minimum of 10 years of experience in biologics discovery or protein sciences
• Leadership experience within the pharmaceutical or biotech industry
• Knowledge in antigen design and generation for antibody discovery; structural biology and protein sequence analysis; biologics discovery workflows from target to lead identification
• Experience or domain knowledge in Oncology, Immunology, and/or Neuroscience

Skills

• Analytical Reasoning
• Biochemistry
• Business Savvy
• Chemistry
• Manufacturing, and Control (CMC)
• Clinical Research and Regulations
• Clinical Trial Designs
• Compliance Management
• Developing Others
• Drug Discovery Development
• Inclusive Leadership
• Leadership
• Molecular Diagnostics
• Operational Excellence
• Pharmacovigilance
• Process Improvements
• Productivity Planning
• Product Strategies
• Program Management
• Scientific Research
• Stakeholder Management

Pay

The anticipated base pay range for this position is: $164,000.00 - $282,900.00

Benefits

• Consolidated Retirement Plan (pension)
• Savings Plan (401(k))
• Long-term incentive program
• Vacation – 120 hours per calendar year
• Sick time – 40 hours per calendar year; for employees who reside in the State of Colorado – 48 hours per calendar year; for employees who reside in the State of Washington – 56 hours per calendar year
• Holiday pay, including Floating Holidays – 13 days per calendar year
• Work, Personal and Family Time – up to 40 hours per calendar year
• Bereavement Leave – 240 hours for an immediate family member: 40 hours for an extended family member per calendar year
• Caregiver Leave – 80 hours in a 52-week rolling period
• Volunteer Leave – 32 hours per calendar year
• Military Spouse Time-Off – 80 hours per calendar year