Director - Oligonucleotide Analytical Chemistry

Responsibilities

• Provide technical leadership for Lilly Genetic Medicine (LGM) analytical activities.
• Drive analytical characterization, biophysical characterization, downstream processing method development, open-access QC workflows, analytical IT, and analytical instrumentation and operation readiness.
• Ensure methods are technically sound, well developed, and fit-for-purpose.
• Partner with the Early Phase Development team and the drug discovery team to define and deliver appropriate analytical data packages to support molecules advancing from discovery to development.
• Mentor and develop scientific team. Ensure continued technical and professional growth of group members, encourage efforts towards excellence and knowledge sharing.
• Plan and manage short-term and long-term analytical investments to support the organization.
• Develop and/or review technical agendas and timelines for project work.
• Recommend resource allocation to accomplish projects according to plans, communicate with LGM leadership on progress, and propose changes in timeline, objectives, or direction.
• Demonstrate high learning agility and the ability to understand and exploit effective scientific concepts and methods across multiple novel drug modalities, including oligonucleotides, antibody-oligonucleotide conjugates, and peptide-oligonucleotide conjugates.
• Manage collaborative partnerships with external and internal analytical vendors to supplement LGM analytical resources.

Qualifications

• Ph.D. in analytical chemistry, bioanalytical chemistry, or a related field with 7+ years of experience in the biopharmaceutical sector following graduation.
• 2+ years of experience in people management and analytical laboratory operations.

Additional Skills/Preferences

• Demonstrated expertise leading analytical efforts in pharmaceutical product discovery and/or development with proven skills developing and validating analytical methods.
• Experience with technical transfer of analytical methods from discovery to development organizations.
• Demonstrated expertise in leading separation sciences for oligonucleotides, including but not limited to RP, HILIC, HIC, IEX, SEC, and CED.
• Demonstrated experience in scale-up sample preparation and analytical characterization of oligonucleotides, antibody-oligonucleotide conjugates, and/or peptide-oligonucleotide conjugates.
• Solid understanding of chemical synthesis, purification, and formulation requirements of drug candidate molecules.
• Proficiency in biophysical and analytical characterization techniques, including but not limited to light scattering methods, chromatography, mass spectrometry, backgrounded membrane imaging, and other molecular-level characterization tools.

Basic Qualifications

• Ph.D. in analytical chemistry, bioanalytical chemistry, or a related field with 7+ years of experience in the biopharmaceutical sector following graduation.
• 2+ years of experience in people management and analytical laboratory operations.