Director, Epidemiology & Methodological Innovation

Key Responsibilities

• Lead the development of novel approaches for RWE, including the use of external control arms (ECA), causal inference in high-dimensional data, and the integration of longitudinal clinical data with molecular/genomic signatures.
• Oversee the end-to-end execution of retrospective database analyses. Act as the primary architect for study protocols, ensuring they push the boundaries of current HEOR/RWE standards while maintaining scientific rigor.
• Serve as a subject matter expert for biopharma clients, advising them on "first-in-kind" study designs. Contribute to the broader scientific community through high-impact publications and presentations at conferences like ISPOR, ISPE, and ASCO.
• Partner with Key Account Directors and Business Development to identify opportunities where novel methodology can solve "unsolvable" client problems (e.g., rare disease characterization or complex biomarker validation).
• Bridge the gap between Data Science, Biostatistics, and Product teams to productize successful novel methods, ensuring they are scalable across the Tempus ecosystem.
• Ensure all innovative research meets stringent regulatory and ethical standards (e.g., GEP, HIPAA), delivering high-quality results on timelines that match the pace of the biopharma industry.

Qualifications

• Education: PhD (preferred) or PharmD in Epidemiology, Biostatistics, Health Economics, or a related quantitative field.
• Experience: 7+ years in HEOR/RWE, with at least 3 years in a leadership capacity. Deep expertise in oncology is required.
• Methodological Mastery: Proven track record of developing or implementing advanced methods (e.g., target trial emulation, propensity score applications in complex cohorts, or machine learning-augmented epidemiology).
• Technical Proficiency: Advanced skills in R or SAS. Experience working with "messy" real-world data (EHR, claims, and/or genomic data) is essential.
• The "Consultant" Mindset: Exceptional ability to walk into a room of biopharma executives and simplify complex methodological hurdles into a clear strategic roadmap.
• Leadership: Demonstrated experience mentoring junior scientists and leading cross-functional squads in a fast-paced, high-growth environment.

Pay

CHI: $170,000-$230,000
NYC/SF: $180,000-$250,000

The expected salary range above is applicable if the role is performed from Illinois and may vary for other locations (California, Colorado, New York). Actual salary may vary based on qualifications and experience.

Benefits

We offer a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position.

About the Role

Tempus is seeking a Director of Epidemiology & Methodological Innovation to join our team. The ideal candidate is a scientific visionary who can translate complex, non-linear data into regulatory-grade insights that accelerate drug development and improve patient outcomes.