Director, DMPK

About the role

We are seeking an experienced, creative, and highly motivated expert with industry research experience in DMPK focused on small molecule lead optimization for discovery research programs, preclinical and clinical drug development.

Responsibilities

• Supervise a group of external DMPK scientists supporting research and development programs.
• Provide scientific guidance on chemical lead optimization programs and work in close collaboration with medicinal chemists to optimize the DMPK properties of candidate drugs.
• Closely interact and effectively communicate with individual research and development groups.
• Ensure complete preclinical DMPK assessment for clinical-stage candidate molecules.
• Understand routes of elimination, levels and identity of circulating metabolites and toxicology coverage as needed.
• Support CTA and IND filings and contribute to clinical development for clinical candidates.
• Perform PKPD modeling for discovery and development projects.
• Manage assigned studies including protocol development, budget, timelines, oversight of outsourced activities, data analysis/interpretation and report writing.

Qualifications

• PhD in chemistry, biochemistry, or related discipline, with 10+ years of pharmaceutical industry experience. In lieu of a PhD, candidates who possess a Bachelor’s or Master’s degree with additional industry experience will be considered.
• A strong background in ADME and pharmacokinetics/pharmacodynamics as applied in small molecule lead optimization.
• Exceptional knowledge of metabolic routes of biotransformation, metabolite identification and the chemistry of drug metabolism are required.
• The candidate should have demonstrated technical knowledge and industrial experience in multiple DMPK areas and an in-depth understanding of the experimental DMPK methodologies and approaches, in vitro and in vivo, utilized in chemical lead optimization.
• The candidate must be able to work with multiple disciplines in drug discovery and provide exceptional guidance to medicinal chemists in the lead optimization process.
• The candidate needs the ability to conduct innovative research in DMPK applied to the discovery of novel drug candidates to achieve defined milestones in a fast-paced environment.
• The candidate should have extensive knowledge of preclinical drug development and may have experience in the preparation of regulatory documents, e.g. INDs and NDAs.
• In addition, she/he should be a goal-oriented individual.
• Additional requirements include highly effective organizational and communication skills.
• The candidate should be self-motivated, with a track record of productivity, demonstrated leadership potential, possess effective interpersonal skills and be team-oriented.
• The preferred candidate would also have experience and knowledge in Clinical Pharmacology.

Pay

The stated pay range for this position reflects the San Francisco Bay Area job market. Assembly Bio establishes pay ranges based on geographic work locations. Additional factors such as academic credentials and relevant experience will influence the actual salary offered.