DirectJobHub
Jobs · Management · Massachusetts

Director, Clinical Supply Chain

Crescent Biopharma · Waltham, MA · 1 wk ago
On-siteManagement$210k–$240k/yrFull-time

Crescent Biopharma’s vision is to build a world-leading oncology company bringing the next wave of therapies for cancer patients. The Company’s clinical-stage pipeline includes its lead program, a PD-1 x VEGF bispecific antibody, as well as novel antibody-drug conjugates. By leveraging multiple modalities and established targets, Crescent aims to rapidly advance potentially transformative therapies as single agents and as part of combination regimens to treat a range of solid tumors.

About the role

We are seeking a Director, Clinical Supply Chain to own clinical supply chain as we advance a multi-program portfolio from Phase 1 to Phase 3. You will ensure clinical supplies move from manufacturing to sites and patients without interruption. This includes forecasting demand, managing CDMOs and depots, overseeing packaging and labeling, and building the processes that don’t yet exist at this scale. You must be comfortable owning an end-to-end function and building it from the ground up.

Responsibilities

  • Own clinical supply strategy for one of our programs from early Phase 1 work through pivotal trials, including the IMP and Standard of Care, when needed
  • Build demand forecasts and supply plans alongside CMC and Clinical Ops, working through the added complexity of combination regimens and trials that span the US, EU, and Greater China
  • Run point on IRT/IWRS systems — vendor selection, system setup, UAT, and the changes that inevitably come up mid-trial
  • Oversee packaging, labeling, and distribution, keeping us compliant with GMP, GCP, and import/export rules that vary by country
  • Manage our CDMO, depot, and logistics partners directly, including contract terms and holding them accountable when something's off
  • Work closely with Regulatory and Quality so supply plans hold up against current expectations in every country we're trialing in
  • Think ahead on risk — expiry timelines, retest strategy, what happens if a shipment gets held up or a comparator becomes hard to source
  • Put real processes and SOPs in place for a function that's still being built, with an eye toward what we'll need as the pipeline grows
  • Own the clinical supply budget and vendor spend, and weigh in on timelines and risk with the broader program teams
  • Be the supply chain voice in cross-functional program meetings and keep leadership in the loop on anything that could affect timelines and costs
  • Mentor junior team members as the team grows

Requirements

  • B.S. and M.S. in Business, Supply Chain, or Engineering
  • 10+ years in clinical supply chain at a biotech, pharma company, or CDMO/CRO working sponsor programs
  • Real experience running clinical supply for biologics. ADC or combination-product experience is a strong plus
  • Background with global, multi-region trials, including the cold chain and handling requirements that come with biologics and ADCs
  • Comfort working hands-on in IRT/IWRS platforms and forecasting tools
  • Solid working knowledge of GMP, GCP, and the import/export rules that govern investigational product across borders
  • A track record of building processes from scratch, not just operating within a function someone else already set up, is a strong plus
  • Confidence negotiating with and managing vendors; you will own those relationships directly, not only monitor them
  • A genuine collaborator — this role touches CMC, Clinical Ops, Regulatory, and Quality constantly, and none of it works if you operate in a silo

Benefits

  • 100% employer-paid benefits package (medical, dental, vision, life insurance, short- and long-term disability)
  • Flexible PTO, plus two one-week company-wide shutdowns each year
  • 10 days of sick time per calendar year
  • Holiday pay, including two company shutdowns
  • 16 weeks of parental leave within one year of the birth/adoption/foster care of a child
  • 401(k) savings plan
  • Long-term incentive program
  • Commitment to professional development, with access to resources, mentorship, and growth opportunities

Pay

The salary range for this position is $210,000 to $240,000. The final salary offered will depend on relevant years of experience, educational background, and geography.

Similar jobs