Director, Clinical Science
Position Summary
We are seeking a Director, Clinical Science to architect trial strategies and protocol execution for our oncology molecular diagnostics portfolio, with a dedicated focus on signal studies and pipeline expansion.
Primary Responsibilities
Design robust clinical study concepts, specifying overall design parameters, schedules of assessments, trial objectives, clinical endpoints, and patient eligibility criteria
Lead clinical development activities and protocol design for oncology Signal Studies and portfolio development
Collaborate cross-functionally to author clinical study protocols, informed consent documents, and technical amendments for internal governance review
Deliver technical protocol validation training to internal teams and contract research organizations (CROs), and guide case report form (CRF) layout configurations
Ensure study manuals conform directly to protocol specifications and engage primary clinical investigators during initial trial design phases
Synthesize protocol requirements from investigators, clinical partners, and regulatory bodies, resolving conflicting operational priorities by anchoring team alignment strictly in data
Partner with cross-functional technical teams to execute clinical programs within exact scope, regulatory compliance, budget, and timeline boundaries
Lead the development of trial execution timelines and deliver unvarnished study status updates to senior leadership
Lead rigorous clinical data review loops to interrogate datasets for specific validation trends, anchoring trial data cleanliness directly in empirical scientific evidence
Collaborate with data management teams to write Data Review Plans, track trial outliers, and audit CRF schemas to confirm absolute data fidelity
Qualifications
Advanced degree in Life Sciences (MD, PhD, PharmD, MS, RN, or equivalent scientific or clinical credential) required
10 or more years of clinical development experience within the pharmaceutical, biotechnology, or diagnostic industry, with a direct focus on oncology trials
Proven track record driving clinical data review workflows, trial data cleaning cycles, protocol development, and technical data reporting
Sound foundational knowledge of FDA regulations, global health authority trial standards, and Good Clinical Practice (GCP) guidelines
Experience directly managing scientific personnel and building cross-functional trial delivery structures
Knowledge, Skills, And Abilities: Technical analytical skills with a proven track record of isolating trial variance and executing target-driven data solutions; Fast learner with the capability to master complex cfDNA platforms, bioinformatics workflows, and molecular assays rapidly; Precise written and verbal communication styles with strict attention to raw data detail and clinical trial parameter boundaries; Proven capability to drive independent portfolios while executing cross-functional objectives within matrixed study teams; High-growth builder mindset with the capability to balance scientific rigor, operational speed, and trial resource constraints under tight timelines; Utilize cloud-based productivity infrastructure to maintain high operational speed in a fast-evolving molecular diagnostics environment
Physical Demands and Work Environment
Modern office or home office environment with reliable, secure internet access infrastructure; Standard requirements for computer operation, telephone communications, and continuous review of scientific data files; Flexibility to engage with clinical collaborators and study teams across international, global time zones; Ability to engage in work-related international and domestic travel up to 25% to manage site performance and support conference execution
Pay Range
The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations.
Our Opportunity
Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.
What We Offer
Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits.
Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more.
We also offer a generous employee referral program!
Equal Opportunity Employer
Natera is committed to ensuring a diverse and inclusive workplace environment, and welcomes people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.
For More Information
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