Director, Clinical Science

About the role

An integral member of the Janux Therapeutics’ Clinical Development team, the Director, Clinical Science will support the strategic planning and execution of clinical-stage programs for one of the company’s early stage oncology platforms. This role partners closely with Clinical Operations to ensure effective trial conduct and supports the Clinical Lead in delivering critical trial milestones. Ideal for individuals passionate about science-driven strategy and immunotherapy innovation.

Responsibilities

• Support the design and implementation of development strategies for programs entering the clinic, providing strategic clinical science input for all assigned programs.
• Collaborate cross-functionally with Clinical Operations team members to support the design and execution of clinical trials, including assistance in the development of essential clinical trial documents such as protocols, ICF documents/amendments, CRFs, CSRs, and Investigator Brochures.
• Aid in the development of the Data Review Plan and Data Review Strategy, ensuring consistent implementation of protocol-level deviations, eligibility criteria, study assessments, and other aspects of the protocol.
• Perform clinical data review and identify clinical data insights through ongoing patient-level review and trends analysis, working cross-functionally to monitor clinical data.
• Promote quality review of data with an emphasis on subject safety and eligibility, data integrity, trend identification, analysis and remediation, and identification of AEs/SAEs for medical review.
• Support ad-hoc Regulatory activities such as contributing by authoring/reviewing clinical portions of Regulatory Documents and/or posters, abstracts, and manuscripts, and the preparation and conduct of meetings with regulatory agencies and/or external drug development consortiums.
• Develop and deliver clinical presentation slides and other materials for internal and external meetings.
• Maintain scientific and clinical knowledge in the specific therapeutic and disease areas of assignment.
• Other duties as required.

Requirements

• BS in life sciences or related field; advanced degree (MS or PhD) in life sciences preferred.
• Minimum 8 years of industry experience, 5+ years of which dedicated to the conduct of clinical trials as a Clinical Scientist.
• Knowledge of oncology drug development and clinical trial processes, study design, statistics, and clinical operations within a similar biotech and/or pharmaceutical environment.
• Skills to support program-specific data review and trend analysis.
• Knowledge of the establishment and operation of data monitoring committees, dose review teams, and independent response adjudication committees.
• Knowledge of GCP and regulatory requirements.
• Ability to critically evaluate data, literature, and presentations.
• Ability to lead and work with cross-functional teams.
• Strong project management skills.

Pay

$236,000 - $255,000 a year (base salary). Individual total compensation will vary based on factors such as qualifications, skill level, competencies, and internal equity.

Benefits

• Annual bonus program and target bonus percentage.
• Incentive stock option plan and restricted stock units.
• Stock purchase plan (ESPP).
• 401k plan with flat non-elective employer contribution.
• Comprehensive medical insurance with 90-100% employer-paid premiums.
• Dental and vision insurance.
• HSA, FSA, and supplemental insurance plans (life, disability, accident, critical illness, hospital indemnity).
• Unlimited PTO.
• Generous holiday schedule, including summer and winter company shutdown.
• Relocation assistance.

Schedule

• Full-time, Monday to Friday.
• On site (San Diego, CA).