Director Clinical Pharmacology & DMPK

Responsibilities

• Lead clinical pharmacology strategy, dose selection, and PK/PD and biomarker planning across early and late-stage programs.
• Conduct and interpret PK, PK/PD, exposure–response, and simulation analyses using tools such as NONMEM, WinNonlin, R, Python, and Simcyp.
• Integrate translational and nonclinical PK/PD data to support FIH dose projections and DDI assessments.
• Oversee bioanalytical CROs, ensuring high-quality PK/PD/biomarker data and GLP/GCP compliance.
• Partner with Clinical Operations on sample management and protocol design.
• Communicate quantitative findings clearly and contribute to regulatory documents (protocols, IBs, INDs, NDAs, IMPDs).
• Collaborate across Clinical Development, Biostats/Data Science, Nonclinical, and Program Management.

Requirements

• PhD, PharmD, or equivalent in Pharmacokinetics, Pharmacology, or related field.
• 6 to 8+ years of industry experience in Clinical Pharmacology, DMPK, or Quantitative Pharmacology.
• Strong expertise in PK, PK/PD, DMPK, and translational sciences.
• Proficiency with modeling/simulation platforms (NONMEM, WinNonlin, Simcyp, R, Python).
• Excellent communication, organization, and ability to work independently in a fast-paced environment.

Qualifications

Alumis Inc. is an equal opportunity employer.

Pay

The salary range for this position is $200,000 USD to $240,000 USD annually.

Schedule

This position is located in South San Francisco, CA and employees are expected to be onsite Tuesday-Thursday.