Director, AI Architecture & Governance

The Importance of the Role

The Director, AI Architecture & Governance is a senior technical leadership role responsible for defining and governing enterprise-scale AI and Generative AI architectures across the life sciences value chain. This role establishes the standards, platform/tooling strategy, and governance frameworks required to deliver AI outcomes safely and at scale, while enabling AI/ML engineering resources to execute efficiently.

This role partners closely with Enterprise Systems, Computer System Validation (CSV), and Enterprise Data Systems (EDS) to ensure AI solutions align with application architecture, validation expectations, and enterprise data governance.

Success requires strong cross-functional collaboration and communication across scientists, engineers, data teams, and executive stakeholders.

The Opportunity to Make a Difference

• Enterprise AI Strategy and Architecture: Define and maintain the enterprise AI reference architecture (data, model, orchestration, and integration patterns) to support scalable delivery across R&D, clinical, and operations.

• Platform Strategy and Tooling: Lead build vs. buy vs. partner decisions and define approved tooling and platform patterns for AI/ML and agentic capabilities.

• Governance, Validation, and Compliance: Establish governance and validation standards for AI/ML solutions, including traceability, auditability, and human oversight, in alignment with CSV and applicable regulatory expectations.

• Data Governance and Security: Define data access and security models for AI systems and partner with EDS to ensure alignment with data governance standards, data ownership, and data quality controls.

• Portfolio Execution Oversight (Not Prioritization): Maintain oversight of the AI use case portfolio to ensure consistent execution against standards and measurable outcomes; business stakeholders set prioritization.

• Cross-Functional Adoption and Alignment: Drive alignment across teams by defining ownership boundaries and ensuring architectural standards translate into implementable patterns and adoption plans.

What Now?

We’re always looking for solution-oriented, critical thinkers. So, if you’re comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply.

What Now?

We’re always looking for solution-oriented, critical thinkers. So, if you’re comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply.

Pay

The targeted salary range for this position is $206,000 - $257,500 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta’s compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity.

Schedule

This position is hybrid, you will be expected to work on site at one of Sarepta’s facilities in the United States and/or attend Company-sponsored in-person events from time to time.