Contract Role - Scientist, Immunology - San Diego, CA

Mirador Therapeutics, Inc. is a clinical-stage precision medicine company focused on developing first-and/or best-in-class next-generation therapeutics for immunology and inflammation. The company’s Mirador360™ precision development engine leverages the latest advances in human genetics and data science to rapidly deliver new precision medicines for patients living with immune-mediated inflammatory and fibrotic diseases. Mirador has raised over $650 million from leading life sciences investors and is based in San Diego, CA.

About the role

We are seeking a motivated, versatile, detail-oriented Contractor who will work with the Immunology Team. This role will focus on preclinical and IND-enabling in vitro studies. The ideal candidate is an individual that enjoys a fast-paced and dynamic work environment.

Responsibilities

• Conceptualize and perform cell-based functional assays (cell lines, primary cells, whole blood) to support target validation, antibody drug screening, mechanism of action studies, biomarker identification and/or companion diagnostics development.
• Work on preclinical and IND-enabling in vitro studies.
• Analyze, critically interpret data and share results to project teams as required.
• Keep meticulous records of experiments performed and maintain ELN entries.
• Work collaboratively with other scientists in the group in a highly matrixed lab environment.

Requirements

• Bachelor’s degree with 6 years or more or Master’s degree with 4 years or more relevant biotech and/or pharmaceutical industry experience.
• Experience with molecular/cell biology techniques such as CRISPR, RT-PCR, cell transfection, cell line generation are required.
• Experience using MSD, Luminex and ELISA to measure analytes in serum, plasma, supernatant or cell lysates is required.
• Experience with transcriptomics studies (e.g., RNAseq, nanostring) are a plus.
• Experience developing ex-vivo models to assess immune responses from human whole blood, PBMCs, and various immune cell subsets.
• Experience with cell-based assays including primary cell and reporter cell assays.
• Experience using multi-color flow cytometry to immunophenotype human cells from blood and tissues is required.
• Experience with Western Blots for samples generated from cell pellets and tissue.
• Experience with protein quantification techniques from tissue samples.
• Experience with tissue explants and organoid systems is a plus.

Skills

• Independent self-motivated life scientist that can generate scientific questions and design experiments to address them.
• Excellent problem-solving and organizational skills.
• Strong interpersonal and communication skills including presenting data to all levels of the organization.
• Scientific rigor and curiosity to address scientific questions and design experiments to test working hypothesis.
• Ability to work in fast-paced and matrix environment to meet project goals.
• Proficiency in data analysis using Excel, GraphPad Prism, and Flow Jo is required.

Pay

The expected base pay range for this position is $105,000 – $115,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training.