Computational Biology & Bioinformatics Lead

Primary Responsibilities

• Train, fine-tune, and benchmark foundation models for protein folding and design, including structure prediction models and generative models for de novo binder and antibody design, and integrate these models for routine use in antigen and antibody discovery projects.
• Build and validate models that predict biophysical properties such as stability, aggregation, expression, binding affinity, and developability, using multimodal data across sequence, structure, next generation sequencing, proteomics, and assay results.
• Run in silico binder and antibody design campaigns and pair them with experimental rounds so predictions are tested and the results feed back into the models.
• Develop pipelines and platforms for in vitro antibody discovery data, protein biophysical characterization, proteomics, and next generation sequencing analysis.
• Build and maintain web portals and databases for large biological datasets, including IPI's external antigen and antibody catalogs (for example OpenAntigens) and internal research databases.
• Work with teams and groups across the Institute to design experiments, interpret and analyze results, and effectively integrate computational tools into established team workflows.
• Manage cloud and high-performance computing environments, including GPU infrastructure for model training and large-scale analysis.
• Lead and mentor a small team of computational biologists and bioinformaticians.
• Effectively present computational analyses to technical and non-technical audiences and contribute to publications, patents, and products.
• Establish standards for data management, version control, reproducibility, and MLOps in the group.

Qualifications

• PhD in computational biology, bioinformatics, biophysics, machine learning, or a related field, with a strong background in protein science or biochemistry.
• 5 or more years of relevant experience, including experience leading or mentoring computational staff or serving as a technical lead.
• Strong Python and hands-on experience with deep learning frameworks such as PyTorch.
• Experience developing, modifying, and applying protein machine learning models for structure prediction and design.
• Experience building or training models on multimodal biological data, with a track record shown through publications, patents, or products.
• Experience with de novo protein and antibody design and validation cycles.

PREFERRED QUALIFICATIONS

• Experience with next generation sequencing analysis.
• Experience building data portals, APIs, or databases for large biological datasets.
• Experience with cloud computing and high-performance computing or GPU environments.
• Familiarity with antibody discovery, proteomics, or protein biophysical characterization assays.
• Experience integrating computational predictions with wet-lab workflows, including LIMS or ELN systems.

Benefits

$200,000 - $240,000 a year
IPI provides competitive compensation and an excellent benefits package to support physical, mental and financial health.
Highlights of benefits include:
- 100% employer-paid medical, dental, and vision plans
- Flexible spending accounts and a healthcare reimbursement account
- 401(k) plan with generous 6% employer match – immediately 100% vested
- Generous PTO package
- Commuter and parking reimbursement
- Career development opportunities