Clinical Scientist

About the role

TScan is seeking a Clinical Scientist with deep expertise in clinical data management and data review to support the execution of our oncology cell therapy clinical programs. This role sits at the intersection of Clinical Development, Clinical Operations, Data Management, and Biostatistics.

Responsibilities

• Serve as the clinical lead for ongoing data review activities across TScan clinical studies.
• Develop and execute comprehensive data review plans to ensure timely identification and resolution of data discrepancies, trends, and potential safety signals.
• Review patient-level clinical data to assess completeness, consistency, protocol compliance, and medical relevance.
• Partner with Clinical Operations, Data Management, Medical, Pharmacovigilance, and Biostatistics to drive data quality and readiness.
• Lead cross-functional data review meetings and track resolution of key data issues.
• Analyze and interpret emerging clinical, safety, efficacy, and biomarker data to support study conduct and decision-making.
• Support data cleaning efforts for interim analyses, data monitoring committee reviews, and regulatory submissions.
• Contribute to clinical narratives, safety analyses, data listings review, and study reports.
• Collaborate with translational and biomarker teams to integrate clinical and correlative data insights.
• Partner closely with Data Management to review CRFs, edit checks, data validation plans, and data review specifications.
• Provide clinical input into database design, study builds, and data collection strategies.
• Support UAT testing of EDC systems and associated clinical technologies.
• Review data transfer specifications and external vendor data integration processes.
• Ensure data review activities align with CDISC standards and regulatory expectations.
• Contribute to the development of innovative approaches for ongoing clinical data surveillance and risk-based data review.
• Leverage data visualization tools and analytics platforms to enhance clinical data review efficiency.
• Help establish scalable processes to support growth of TScan's clinical portfolio.

Qualifications

• Advanced degree (PharmD, PhD, MS, MPH, or equivalent) in a life sciences, clinical research, or related field preferred.
• Bachelor's degree with significant relevant experience may be considered.
• 5+ years of experience in clinical development, clinical science, data management, or related functions within biotechnology, pharmaceutical, or CRO environments.
• Demonstrated experience performing ongoing clinical data review in oncology or advanced therapy clinical trials.
• Experience working closely with Data Management and Biostatistics teams.
• Experience supporting early- and/or late-stage clinical trials.
• Oncology, immuno-oncology, cell therapy, CAR-T, TCR-T, or hematology experience strongly preferred.
• Strong understanding of clinical trial conduct, GCP, ICH guidelines, and regulatory requirements.
• Hands-on experience with EDC systems (e.g., Medidata Rave, Veeva EDC, Oracle Inform).
• Experience using clinical data review and visualization tools such as Spotfire, Tableau, JReview, SAS, or similar platforms.
• Familiarity with CDISC standards (SDTM, ADaM) and clinical database structures.
• Strong analytical and problem-solving skills with the ability to interpret complex clinical datasets.
• Understanding of external data sources, including laboratory, imaging, biomarker, and pharmacokinetic data.
• Strong scientific curiosity and attention to detail.
• Excellent communication and presentation skills.
• Proven ability to work effectively in highly cross-functional teams.
• Comfortable operating in a fast-paced, evolving biotechnology environment.
• Strong organizational skills with the ability to manage multiple priorities simultaneously.

About TScan

TScan Therapeutics is a fully integrated, next-generation TCR-T cell therapy company. Founded in 2018, TScan's platform was developed by Stephen Elledge, Ph.D., and Tomasz Kula, Ph.D., at Brigham and Women's Hospital and Harvard Medical School. TScan's transformative platform enables rapid discovery of TCRs and targets for engineered T cell therapy. This technology is extremely versatile and is applicable across multiple therapeutic areas beyond cancers, including autoimmune disorders and infectious diseases.

EEO Statement

TScan is proud to be an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, citizenship status, sexual orientation, gender identity or expression, or any other characteristic identified by federal, state, or local laws where we operate. TScan provides reasonable accommodations to qualified applicants and employees with disabilities. To begin an interactive dialogue with TScan regarding a reasonable accommodation in connection with the hiring process and/or to perform the responsibilities of the position for which the applicant has applied, please contact the recruiter.