Clinical Genomics Scientist III

About the role

Baylor Genetics, one of the world leaders in clinical molecular genetics, has an opening in the Clinical Genomics Interpretation (CGI) division. The Clinical Genomics Scientist analyzes clinical genetics data, curates variants and genes, and summarizes findings for clinical reports. Our scientists assist laboratory directors and R&D with validation of cutting-edge technologies and software platforms. This position is a remote work opportunity, with daily huddles, clear objectives, and flexible scheduling. Minimal on-site time at the headquarters in Houston, TX may be required.

Key responsibilities

• 50%: curation of variants, genes, and gene-disease correlations following ACMG guidelines, using our robust internal dataset, online resources, and published literature
• 30%: analyzing clinical genomics data, including next-generation sequencing, Sanger sequencing, metabolomics, and chromosomal microarray
• 10%: clinical report drafting
• 10%: validation, process refinement, presenting findings at meetings, and performing other duties as needed
• Performs other job-related duties as assigned

Required knowledge and skills

• Knowledge of genomic variation and its relationship to human disease
• Knowledge of literature curation methodologies
• Knowledge of variant detection, molecular mechanisms of disease, functional assays, and computational analysis
• Technical expertise in clinical medicine, genetics, genomics, or molecular biology
• Experience with data quality assessment
• Excellent verbal and written communication skills
• Proficiency in communicating an understanding of genetics details
• Knowledge of principles and practices of data analysis as applied to experimental results
• Experience in the application of ontologies for medical/biological annotation

Desired skills

• An understanding of bioinformatics analysis to identify variants within genomic data sets, and variant effect prediction algorithms
• Experience with use of Perl, Python, or other programming language
• Ability to create scripts and process large quantities of data

Qualifications

Clinical Genomic Scientist I
Degree: PhD or MD level degree in clinical medicine, genetics, molecular biology, or an equivalent subject. Strong candidates with a Master's degree and appropriate experience will be considered.
Relevant experience: 0-2 years
Certification (optional): MB(ASCP)

Clinical Genomic Scientist II
Degree: PhD or MD level degree in clinical medicine, genetics, molecular biology, or an equivalent subject. Strong candidates with a Master's degree and appropriate experience will be considered.
The Clinical Genomic Scientist II demonstrates a strong understanding of the principles of variant curation and genetic data analysis.
Relevant experience: 2-4 years
Certification (optional): MB(ASCP)

Clinical Genomic Scientist III
Degree: PhD or MD level degree in clinical medicine, genetics, molecular biology, or an equivalent subject. Strong candidates with a Master's degree and appropriate experience will be considered.
The Clinical Genomic Scientist III demonstrates a consistent high level of performance and leadership abilities.
Relevant experience: 4-7 years
Certification (optional): MB(ASCP)

Senior Clinical Genomic Scientist
Degree: PhD or MD level degree in clinical medicine, genetics, molecular biology, or an equivalent subject.
The Senior Clinical Genomic Scientist demonstrates initiative, innovation, and process improvement abilities.
Relevant experience: 7+ years
Certification (optional): MB(ASCP)

Physical demands and work environment

• Location: Onsite / Hybrid / Remote
• Frequently required to sit or stand
• Frequently required to utilize hand and finger dexterity to operate keyboard
• Frequently required to attend virtual meetings, listen, and talk
• Occasionally required to work additional hours to complete tasks, with compensatory time-off provided