Clinical Genomic Scientist- WGS Analysis

This fully remote position plays a central role in our whole genome sequencing operation, focusing on clinical documentation review, case analysis, candidate variant selection, and collaboration with other clinical reporting teams.

About the role

We seek candidates with a strong understanding of gene-disease correlation, molecular mechanism, inheritance, and evaluating the clinical relevance of genetic findings. The role offers daily team huddles, clear objectives, and flexible scheduling—all from the comfort of your home office.

Why Baylor Genetics?

• Work at the forefront of genomic medicine with a team of world-class scientists.
• Contribute to innovations that shape the future of personalized healthcare.
• Enjoy a collaborative environment that values expertise, growth, and impact.

Responsibilities

• 80%, possibly up to 100%: Review test requisition forms and clinical notes; perform case analysis using the Emedgene platform; identify and select variants relevant to the proband’s phenotype; and request confirmatory testing when necessary.
• Communicate findings at cross-team huddles.
• Up to 20%: As needed, opportunities for cross-training in WGS variant curations or clinical indication (HPO) may become available.

Requirements

For all ranks:

• Degree: Masters in Genetic Counseling, MD, or PhD in clinical medicine, genetics, molecular biology, or equivalent.
• Familiarity with American College of Medical Genetics (ACMG) variant curation guidelines.

Qualifications

• Clinical Genomic Scientist - WGS review I: 1 year of prior experience with whole exome or whole genome case review is preferred.
• Clinical Genomic Scientist - WGS review II: 2 years of experience with whole exome or whole genome case review is preferred.
• Clinical Genomic Scientist - WGS review III: 5 years of experience with whole exome or whole genome case review is preferred.
• Clinical Genomic Scientist - WGS review - Senior: 7 years of experience with whole exome or whole genome case review is preferred, plus demonstration of thorough expertise in gene-disease correlation, case analysis, and variant selection.
• Clinical Genomic Scientist - WGS review - Professional: 10 years of experience with whole exome or whole genome case review is preferred, plus demonstration of thorough expertise in gene-disease correlation, case analysis, variant selection, a track record of high-quality work, leading projects toward goals, training coworkers, and workflow process improvement.

Skills

• Expertise in concepts of clinical medicine, genetics, genomics, and molecular biology.
• Knowledge of genomic variation and its correlation with human disease.
• Familiarity with American College of Medical Genetics (ACMG) variant curation guidelines.
• Experience in communicating genetic details effectively.
• Proficiency in Microsoft Office (Excel, Word, PowerPoint, Outlook).
• Competencies: Quality Assurance, Analytical and Problem-Solving Skills, Technical Skills, Interpersonal Skills, Oral and Written Communication, Teamwork, Organizational Support, Safety and Security, Dependability, Innovation, Adaptability.

Schedule

• Fully remote with flexible scheduling.
• Occasional weekend rotation may be needed (e.g., once a month).

Physical Demands and Work Environment

• Frequently required to sit, using a screen, keyboard, and mouse.
• Punctuality attending virtual meetings.