Biomarker Scientist - LCMS

About the role

This position supports a Neuroscience Biomarkers client team focused on LC-MS-based proteomics to identify and quantify biomarkers associated with neurodegenerative diseases, including Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis. We seek a motivated scientist eager to gain hands-on experience in LC-MS proteomics workflows applied to CSF, plasma, and tissue biomarker studies, and to grow technical skills in a collaborative, fast-moving research environment.

Principal responsibilities will include weekly and monthly lab operations tasks (approximately 70% effort) while additional responsibilities will include routine testing (approximately 30% effort).

Responsibilities

• Lab Operations:
  • Manage lab instruments, consumables, and chemicals/reagents.
  • Manage lab supply and reagent inventory, including aliquoting, ordering, and stocking.
  • Perform sample management, including sorting, storage, and manifest recording in Benchling (ELN).
  • Prepare reagents and solutions for proteomics and biochemistry workflows.
  • Coordinate with the facilities team to manage instrument servicing and preventive maintenance schedules.
• Analytical Testing:
  • Perform biochemistry assays, including sample preparation and Western Blotting using human or animal biospecimen.
  • Perform LC-MS support tasks including instrument source cleaning, monthly QC runs, mobile phase and buffer preparation, and sample injection on Thermo Orbitrap and Sciex triple quadrupole platforms.
  • Process and analyze data generated from biochemistry and LC-MS assays under scientist supervision and contribute to summarizing and reporting findings.
  • Maintain accurate and detailed records in the electronic laboratory notebook (ELN).

Qualifications

Basic Minimum Qualifications:

• B.S. in Biochemistry, Molecular Biology, Biotechnology, Immunology, Neuroscience, or related field with at least 2 years of LC-MS experience in the pharmaceutical industry including setup, cleaning, and monthly QC runs.
• Demonstrated hands-on experience with biochemistry and molecular biology techniques, including protein sample preparation, Western Blotting, and buffer preparation.
• Ability to follow and troubleshoot established laboratory protocols independently after training, including identifying and escalating reagent, instrument, or assay issues.

Preferred Qualifications:

• Experience with LC-MS in proteomics workflows.
• Familiarity with automated liquid handlers, Thermo Orbitrap instruments, or Sciex triple quadrupole platforms.
• Authorization to work in the United States indefinitely without restriction or sponsorship.

Benefits

• Comprehensive medical coverage, dental, and vision options
• Life and disability insurance
• 401(k) with company match
• Paid vacation and holidays
• Eligibility for yearly goal-based bonus & merit-based increases

Pay

$31.00-$41.00 per hour based on education and related experience.

Schedule

Full-time, Monday-Friday, 8am-5pm with overtime as needed.

Candidates living within a commutable distance of Boston, MA are encouraged to apply.